Hyperthermia induced changes in liver physiology and metabolism: A rationale for hyperthermic machine perfusion.

Hyperthermia induced changes in liver physiology and metabolism: A rationale for hyperthermic machine perfusion. Am J Physiol Gastrointest Liver Physiol. 2020 Jun 08;: Authors: Thorne AM, Ubbink R, Brüggenwirth IMA, Nijsten MW, Porte RJ, de Meijer VE Abstract Liver transplantation is the standard treatment for end-stage liver disease. However, due to the ongoing disparity between supply and demand for optimal donor organs, there is increasing usage of extended criteria donor organs, including steatotic liver grafts. To mitigate the increased risks associated with extended criteria donor livers, ex-situ oxygenated machine perfusion (MP) has received increasing attention in recent years as an emerging platform for dynamic preservation, reconditioning and viability assessment to increase organ utilisation. MP can be applied at different temperatures. During hypothermic MP (4-12°C), liver metabolism is reduced, while oxygenation restores the intracellular levels of adenosine triphosphate. The liver is quickly 'recharged' to support metabolism when at normothermia (35-37°C), and to ameliorate the detrimental effects of ischemia/reperfusion injury during transplantation. During normothermia, MP can be applied to assess hepatocellular and cholangiocellular viability. MP at hyperthermic (>38°C) temperatures (HyMP), however, remains relatively understudied. The liver is an important component in the regulation of core body temperature ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - Category: Physiology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research