Effects of Porphyromonas gingivalis and Fusobacterium nucleatum on inflammasomes and their regulators in H400 cells

ConclusionPg alone increased IL ‐1β by upregulating AIM2, NLRP3 and downregulating POP1.Fn promoted IL ‐1β by increasing AIM2 and downregulating POP1.Pg+ATP with or withoutFn upregulated NLRP3, IL ‐1β by downregulating POP1. Periodontal pathogens may contribute to HNSCC pathogenesis by increasing the IL‐1β response due to inflammasome dysregulation.

Source: Molecular Oral Microbiology - June 8, 2020 Category: Microbiology Authors: K übra Aral, Michael R Milward, Dhanak Gupta, Paul R Cooper Tags: ORIGINAL ARTICLE Source Type: research