Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder at Any Phase of Illness and at least Mild Symptom Severity.

Conclusions: The efficacy of lithium and divalproex as monotherapy was modest. Adjunctive lamotrigine and quetiapine to either one was well-tolerated and equally effective in reducing bipolar symptomatology, but adjunctive therapy should be initiated as early as possible when depression symptoms are present. PMID: 32508363 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32508363?dopt=Abstract

Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research