Grand Rounds: Presentation of a Large and Debilitating Fungating Anogenital Lesion

A 65-year-old Caucasian man presented with a 24-year history of perineal leakage, bleeding, and mobility limitations associated with enlarging anogenital mass. He delayed addressing this issue due to myocardial infarction and cardiac stenting requiring long-term anticoagulation. Other past medical history included diabetes mellitus, chronic kidney disease, obstructive sleep apnea, hypertension, and benign prostatic hyperplasia. He never pursued a biopsy or culture of the area.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research

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Resumen Paciente de 78 a ños consulta por sangrado sin resolución, a nivel del reborde alveolar maxilar izquierdo. Con antecedentes de metástasis óseas tratadas con ácido zoledrónico endovenoso discontinuado por alta médica y tratamiento quirúrgico previo de osteonecrosis maxilar en sitio afectado. Se observó disru pción de continuidad con inflamación a nivel del reborde óseo, con salida de contenido hemático, purulento y necrótico. Radiográficamente se observó radiolucidez difusa y osteolítica del á...
Source: Odontoestomatologia - Category: Dentistry Source Type: research
Background Gingivitis and periodontitis are prevalent inflammatory diseases of the periodontal tissues. Current treatments are often ineffective or do not prevent disease recurrence. Uncontrolled complement activation and the resulting chronic gingival inflammation are hallmarks of periodontal diseases. We determined the efficacy and safety of a complement 3–targeted therapeutic, AMY-101, which was locally administered to adult patients with periodontal inflammation.Methods Thirty-two patients with gingival inflammation were enrolled in a randomized, placebo-controlled, double-blind, split-mouth phase IIa trial that ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Insulin resistance is a cornerstone of obesity-related complications such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. A high rate of lipolysis is known to be associated with insulin resistance, and inhibiting adipose tissue lipolysis improves obesity-related insulin resistance. Here, we demonstrate that inhibition of serotonin (5-hydroxytryptamine [5-HT]) signaling through serotonin receptor 2B (HTR2B) in adipose tissues ameliorates insulin resistance by reducing lipolysis in visceral adipocytes. Chronic high-fat diet (HFD) feeding increased Htr2b expression in epididymal white adipose tis...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
PURPOSE: To report the computed tomography features of a case with complete luxation of the globe after a road traffic accident. CASE REPORT: A 35-year-old male presented with pain, loss of vision, and bleeding from the left eye 48 hr after a road traffic ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Condition:   Bariatric Surgery Candidate Intervention:   Sponsor:   Imperial College London Diabetes Centre Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Metabolic-associated Fatty Liver Disease;   Type 2 Diabetes Interventions:   Drug: Empagliflozin;   Drug: Dulaglutide;   Drug: Empagliflozin and Dulaglutide Sponsor:   Seoul National University Bundang Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Drug Interactions;   Hypertension Intervention:   Sponsor:   Instituto Mexicano del Seguro Social Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Diabetes Mellitus, Type 1;   Eating Disorders Intervention:   Behavioral: STEADY intervention Sponsor:   King's College London Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Diabetes Mellitus;   Diabetes Mellitus, Type 2;   Diabetes Mellitus, Type 1;   Diabetes;   Depression;   Anxiety;   Distress, Emotional;   Diabetes Distress;   Loneliness;   Social Functioning;   Quality of Life Intervention:   Device: COMPASS: digital CBT Sponsors:   King's College London;   South London and Maudsley NHS trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Diabetic Retinopathy Intervention:   Device: OCT angiography Sponsor:   Kareem Mohammad Ali Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Benign Prostatic Hyperplasia | Bleeding | Chronic Kidney Disease | Diabetes | Diabetes Mellitus | Endocrinology | Heart Attack | Hypertension | Obstructive Sleep Apnea | Sleep Apnea | Sleep Disorders | Sleep Medicine | Urology & Nephrology