Role of microRNAs in Staphylococcus aureus infection: Potential biomarkers and mechanism
AbstractStaphylococcus aureus is known as a common pathogen that colonizes 30% of healthy humans. Additionally, this bacterium can cause a number of serious infections, that is, endocarditis, bacteremia, pneumonia, wound, skin infections, and tissue abscesses. A variety of cellular and molecular pathways and targets are involved in response againstS. aureus. Among them, microRNAs (miRNAs) have crucial roles in response againstS. aureus. In this regard, it has been shown that these molecules exert their regulatory roles via modulating a wide range of events, such as inflammatory reactions, host innate, and adaptive immunity. Current works have provided insight into the crucial involvement of miRNAs in immune defense toward Staphylococcal infections. Herein, we highlighted the current findings on the deregulation of different miRNAs inS. aureusâinfected cells. Moreover, we summarized the mechanisms and targets of miRNAs inS. aureus infections.
Source: IUBMB Life - Category: Research Authors: Rasoul Mirzaei,
Rokhsareh Mohammadzadeh,
Hamed Mirzaei,
Mohammad Sholeh,
Sajad Karampoor,
Milad Abdi,
Mohammad Yousef Alikhani,
Sima Kazemi,
Yaghoub Ahmadyousefi,
Saba Jalalifar,
Rasoul Yousefimashouf Tags: CRITICAL REVIEW Source Type: research