Lung and eye disease develop concurrently in supplemental oxygen-exposed neonatal mice

Bronchopulmonary dysplasia and retinopathy of prematurity are two debilitating disorders that develop in preterm infants exposed to supplemental oxygen to prevent respiratory failure. Both can lead to lifelong disabilities such as chronic obstructive pulmonary disease and vision loss. Due to the lack of a standard experimental model of coincident disease, the underlying associations between BPD and ROP are not well characterized. To address this gap, the robust mouse model of oxygen-induced retinopathy was employed exposing C57BL/6 mice to 75% oxygen from postnatal day (PN) 7 to 12.

Source: American Journal of Pathology - June 7, 2020 Category: Pathology Authors: Lakshanie C. Wickramasinghe, Maverick Lau, Devy Deliyanti, Timothy A. Gottschalk, Peter van Wijngaarden, Dean Talia, Chad Johnson, Jennifer L. Wilkinson-Berka, Evelyn Tsantikos, Margaret L. Hibbs Source Type: research