Epstein –Barr virus-associated gastric cancer: disease that requires special approach

AbstractEpstein –Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenot ype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV( +) GC also has a unique epigenetic profile and mutational status with frequent mutations ofPIK3CA,ARID1A andBCOR,and PD-L1 andPD-L2 amplifications, as well. The aim of this review is to highlight clinical significance of EBV(  +) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research