Secondary analysis of RTOG 0247 demonstrates favorable OS rates for rectal cancer patients

(American Society for Radiation Oncology) Locally advanced rectal cancer patients who receive preoperative radiation therapy with either irinotecan plus capecitabine or oxaliplatin plus capecitabine have a four-year overall survival rate of 85 percent and 75 percent, respectively, according to a study published in the January 1, 2015 issue of the International Journal of Radiation Oncology * Biology * Physics, the official scientific journal of the American Society for Radiation Oncology.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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ConclusionsHere we report the completion rates for neoadjuvant CTx and adjuvant CTx, the pathological complete response rate, and the mid-term prognosis. The results indicate that CAPOX followed by TME may be a safe treatment strategy for locally advanced rectal cancer.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Publication date: September 2018Source: The American Journal of Surgery, Volume 216, Issue 3Author(s): Morgan L. Cox, Mohamed A. Adam, Mithun M. Shenoi, Megan C. Turner, Zhifei Sun, Christopher R. Mantyh, John MigalyAbstractBackgroundOur study aims to identify the minimum number of lymph nodes (LN) associated with improved survival in patients who underwent NRT for stage II-III rectal cancer.MethodsAdults with clinical stage II and III rectal adenocarcinoma in the National Cancer Data Base were stratified by NRT. Multivariable Cox regression modeling with restricted cubic splines was used to determine the minimum number of...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Abstract Intensity-modulated radiation therapy is recommended in anal squamous cell carcinoma treatment and is increasingly used in rectal cancer. It adapts the dose to target volumes, with a high doses gradient. Intensity-modulated radiation therapy allows to reduce toxicity to critical normal structures and to consider dose-escalation studies or systemic treatment intensification. Image-guided radiation therapy is a warrant of quality for intensity-modulated radiation therapy, especially for successful delivery of the dose as planned. There is no recommended international or national anorectal cancer image-guide...
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
Publication date: Available online 17 August 2018Source: Journal of Visceral SurgeryAuthor(s): T. Sarcher, B. Dupont, A. Alves, B. MenahemSummaryMultidisciplinary management of infra-peritoneal rectal cancer has pushed back the frontiers of sphincter preservation, without impairment of carcinological outcome. However, functional intestinal sequelae, grouping together several symptoms known under the name of anterior resection syndrome (ARS), have emerged and become an increasingly frequent concern for both patients and physicians. The pathophysiology is complex: ARS is a combination in various degrees of stool frequency, i...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
Conditions:   Rectal Cancer;   Metastasis;   Radiotherapy Intervention:   Combination Product: IMRT + oral chemotherapy Sponsor:   Institut Cancerologie de l'Ouest Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionPre-operative MRI in cancer rectum is irreplaceable to assess initial staging and post-neoadjuvant therapy response thus improving surgical results.
Source: Alexandria Journal of Medicine - Category: General Medicine Source Type: research
ConclusionsHere we report the completion rates for neoadjuvant CTx and adjuvant CTx, the pathological complete response rate, and the mid-term prognosis. The results indicate that CAPOX followed by TME may be a safe treatment strategy for locally advanced rectal cancer.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
The objective of this study was to assess whether the status of the mesorectal fascia versus a stage II/III designation can best inform the use of preoperative RT in patients undergoing major rectal cancer resection. METHODS: We reviewed the charts of consecutive patients with primary rectal cancer treated by a single surgeon at McMaster University, Hamilton, Ontario, between March 2006 and December 2012. The status of the mesorectal fascia was assessed by digital rectal examination, pelvic computed tomography and, when needed, pelvic magnetic resonance imaging (MRI). Patients whose mesorectal fascia was threatened or...
Source: Canadian Journal of Surgery - Category: Surgery Authors: Tags: Can J Surg Source Type: research
In vivo measurements using three 1.5  × 1.5 cm2 pieces of Gafchromic EBT3 film are part of our routine quality assurance during electron intra-operative radiation therapy (IOERT) for rectal cancer. The complexity of the pelvic irradiation geometry makes it desirable to increase the number of film samples, to ensure complete cove rage of the irradiated length. The positioning of small films for digitization is time consuming and challenging, because of the need to minimize undesirable scanning artifacts.
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Source Type: research
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