Secondary analysis of RTOG 0247 demonstrates favorable OS rates for rectal cancer patients

(American Society for Radiation Oncology) Locally advanced rectal cancer patients who receive preoperative radiation therapy with either irinotecan plus capecitabine or oxaliplatin plus capecitabine have a four-year overall survival rate of 85 percent and 75 percent, respectively, according to a study published in the January 1, 2015 issue of the International Journal of Radiation Oncology * Biology * Physics, the official scientific journal of the American Society for Radiation Oncology.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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In this study, patients with non-metastatic locally advanced rectal cancer (tumor stages of T2, T3, or T4) with or without lymph node involvement were retrospectively included. Patients received concomitant radiation (50.4-54 Gy external beam radiation in 28 to 30 fractions) and neoadjuvant therapy as either Xeloda (capecitabine, 2500 mg/m2 concomitantly with radiation therapy) (42patients) or XELOX [(oxaliplatin (50 mg/m2 intravenously once a week for five weeks) and capecitabine)] (72 patients). Surgery was done eight weeks after CRT. The endpoints were pCR (defined as no evidence of viable tumoral cells) ...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
Rationale: Fluoropyrimidine-induced cardiotoxicity is a rare but potentially serious toxicity. The most common symptom is anginal chest pain. Patient concerns: A 35-year-old woman was diagnosed with rectal cancer with metastasis to the liver. Diagnosis: A computed tomography scan showed a 9.3 × 4.5-cm predominantly hypodense lesion within the left lobe of the liver and thickening of the rectum. Liver biopsy showed moderately differentiated adenocarcinoma with necrosis involving the liver parenchyma, and immunohistochemistry for mismatch repair proteins indicated that the tumor was positive for MutL Homolo...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusions: Dose-escalation and consolidation chemotherapy leads to increased long-term organ-preservation rates among cT2N0 rectal cancer. After achievement of a cCR, the risk for local recurrence and need for salvage surgery is similar, irrespective of the CRT regimen.
Source: Annals of Surgery - Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research
ConclusionThe whole-tumor ADC mean combined with the tumor volume was highly accurate for predicting pCR. The IVIM models were inferior to ADC and SEM at predicting pCR.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Neoadjuvant radio- or chemoradiation (nIRT) therapy is the standard treatment for loco-regional advanced rectal cancer patients of the lower or middle third. Currently, intensity modulated radiation therapy (I...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
ConclusionsIn the combined national population-based registries, a minority of patients with rectal cancer had an AR after previous radiotherapy for prostate cancer. These patients were healthy with early cancer stages and, in this selected group of patients, the AL rate was much lower than that reported previously.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 15 November 2018Source: Stem Cell ReportsAuthor(s): Dengbo Ji, Tiancheng Zhan, Ming Li, Yunfeng Yao, Jinying Jia, Haizhao Yi, Meng Qiao, Jinhong Xia, Zhiqian Zhang, Huirong Ding, Can Song, Yong Han, Jin GuSummaryChemo-/radiotherapy resistance is the main cause accounting for most treatment failure in colorectal cancer (CRC). Tumor-initiating cells (TICs) are the culprit leading to CRC chemo-/radiotherapy resistance. The underlying regulation mechanism of TICs in CRC remains unclear. Here we discovered that miR-15b expression positively correlated with therapeutic outcome in CRC. Expressio...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Condition:   Rectal Cancer Intervention:   Combination Product: radiotherapy, capecitabine, oxaliplatin Sponsors:   Uppsala University;   Swedish Cancer Society Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsHere we report the completion rates for neoadjuvant CTx and adjuvant CTx, the pathological complete response rate, and the mid-term prognosis. The results indicate that CAPOX followed by TME may be a safe treatment strategy for locally advanced rectal cancer.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
There are 2 main standards of preoperative radiotherapy for rectal cancer, including short-course radiation therapy (RT) and conventional long-course RT. The pathological response in surgical specimens for preoperative RT was superior in long-course RT compared with in short-course RT; however, previous studies revealed no difference between these 2 therapies in terms of survival and local recurrence. We investigate a direct comparison between short- and long-course CRT in clinicopathological responses and oncological outcome in patients with curatively resected rectal cancer, and assess the predictive factor for recurrence in each treatment.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Scientific poster presentations Source Type: research
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