Bone ‐specific Metabolism of Dietary Polyphenols in Resorptive Bone Diseases

ConclusionsDietary polyphenols circulating as glucuronides may require in situ deconjugation for bone protective effects, a process influenced by bone microenvironmental changes. Curcumin and other dietary polyphenols are bone protective and block RANKL ‐stimulated osteoclastogenesis. Inactive glucuronide metabolites circulating in vivo are deconjugated locally in bone by ß‐glucuronidase (GUSB) to form the bioactive aglycones. Bone GUSB and aglycone levels remain fairly constant across skeletal development and resorptive diseases, including hi gh turnover states, like osteoporosis, where bone glucuronide substrate levels are increased.This article is protected by copyright. All rights reserved

Source: Molecular Nutrition and Food Research - June 6, 2020 Category: Food Science Authors: Andrew G Kunihiro, Paula B Luis, Jennifer B Frye, Wade Chew, H ‐H. Sherry Chow, Claus Schneider, Janet L Funk Tags: Research Article Source Type: research