Stromal Cell-Derived Factor (SDF) 2 and the Endoplasmic Reticulum Stress Response of Trophoblast Cells in Gestational Diabetes Mellitus and in vitro Hyperglycaemic Condition.

CONCLUSION: Our findings extend the understanding of ER stress and SDF2 expression in placentae exposed to hyperglycaemia, highlighting the relevance of insulin in reducing the levels of ER stress factors in placental cells. Understanding the effect of ER stress partners such as SDF2 on signalling pathways involved in gestation, complicated by hyperglycaemia, is pivotal for basic biomedical research and may lead to new therapeutic possibilities.
PMID: 32504504 [PubMed - as supplied by publisher]

Source: Current Vascular Pharmacology - June 5, 2020 Category: Drugs & Pharmacology Authors: Lorenzon AR, Moreli JB, de Macedo Melo R, Namba FY, Staff AC, Yung HW, Burton GJ, Bevilacqua E Tags: Curr Vasc Pharmacol Source Type: research