Toll-like receptor 7-driven lupus autoimmunity induces hypertension and vascular alterations in mice

Conclusion: Our results demonstrate that TLR7 activation induces the development of hypertension and vascular damage in BALB/c mice, and further underscore the increased vascular inflammation and oxidative stress, mediated in part by IL-17, as key factors contributing to cardiovascular complications in this TLR7-driven lupus autoimmunity model.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research