Renin angiotensin system inhibition attenuates adipocyte-breast cancer cell interactions.

Renin angiotensin system inhibition attenuates adipocyte-breast cancer cell interactions. Exp Cell Res. 2020 Jun 03;:112114 Authors: Rasha F, Ramalingam L, Menikdiwela K, Hernandez A, Moussa H, Gollahon L, Rahman RL, Moustaid-Moussa N Abstract Obesity is a significant breast cancer (BC) risk factor and is associated with 20-40% increased risk in obese post-menopausal women compared to their lean counterparts. Several obesity-related metabolic dysregulations have been linked to BC risk, including overactivation of the renin-angiotensin system (RAS). Currently, RAS inhibitors including angiotensin converting enzyme inhibitor (ACEi) and AT1 receptor blockers (ARBs), are used as safe and effective anti-hypertensive therapies in BC patients. However, it is uncertain how inhibition of RAS in adipose tissue impacts obesity-BC crosstalk. We hypothesized that adipose RAS inhibition will reduce BC cell motility and inflammation. We determined (1) the direct effects of Ang II, ACEi (captopril; Cap) or ARB (telmisartan; Tel) on receptor positive MCF-7 and receptor triple negative MDA-MB-231 cells; and (2) the effects of conditioned media (CM) from human mesenchymal stem cells differentiated into adipocytes, which were pretreated with RAS inhibitors, on BC cells. We demonstrated that direct treatments of BC cells with Ang II, Cap or Tel did not alter inflammatory cytokines in either BC cell line. CM from Ang II-pretreated adipocytes significant...
Source: Experimental Cell Research - Category: Cytology Authors: Tags: Exp Cell Res Source Type: research