Revisiting the role of brain and peripheral a β in the pathogenesis of Alzheimer's disease

Amyloid beta (A β) is an intricate molecule that interacts with several biomolecules and/or produces insoluble assemblies and eventually the nonphysiological depositions of its alternate with normal neuronal conditions leading to Alzheimer’s disease (AD). Aβ is formed through the proteolytic cleavage of an inte gral type I membrane protein amyloid precursor protein (APP). Significant efforts are being made to explore the exact role of Aβ in AD pathogenesis. It is believed that the deposition of Aβ in the brain takes place from Aβ components which are derived from the brain itself.

Source: Journal of the Neurological Sciences - June 5, 2020 Category: Neurology Authors: Md. Sahab Uddin, Md. Tanvir Kabir, Devesh Tewari, Abdullah Al Mamun, Bijo Mathew, Lotfi Aleya, George E. Barreto, May N. Bin-Jumah, Mohamed M. Abdel-Daim, Ghulam Md Ashraf Tags: Review Article Source Type: research