Current processes and future challenges of photoautotrophic production of acetyl-CoA-derived solar fuels and chemicals in cyanobacteria.

Current processes and future challenges of photoautotrophic production of acetyl-CoA-derived solar fuels and chemicals in cyanobacteria.
Curr Opin Chem Biol. 2020 Jun 02;59:69-76
Authors: Miao R, Xie H, Liu X, Lindberg P, Lindblad P
Abstract
The production of fuels and other valuable chemicals via biological routes has gained significant attention during last decades. Cyanobacteria are prokaryotes that convert solar energy to chemical compounds in vivo in direct processes. Intensive studies have been carried out with the aim of engineering cyanobacteria as microfactories for solar fuel and chemical production. Engineered strains of photosynthetic cyanobacteria can produce different compounds on a proof-of-concept level, but few products show titers comparable with those achieved in heterotrophic organisms. Efficient genetic engineering tools and metabolic modeling can accelerate the development of solar fuel and chemical production in cyanobacteria. This review addresses the most recent approaches to produce solar fuels and chemicals in engineered cyanobacteria with a focus on acetyl-CoA-dependent products.
PMID: 32502927 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - June 1, 2020 Category: Biochemistry Authors: Miao R, Xie H, Liu X, Lindberg P, Lindblad P Tags: Curr Opin Chem Biol Source Type: research