Chiral-phase resolution of sesquilignans from raspberries (Rubus idaeus L.) and their neuroprotective effects.

Chiral-phase resolution of sesquilignans from raspberries (Rubus idaeus L.) and their neuroprotective effects.
Fitoterapia. 2020 Jun 02;:104655
Authors: Lu LW, Le-Zhou, Hou ZL, Jie-Wang, Yao GD, Lin B, Huang XX, Song SJ
Abstract
Two pairs of diastereoisomers (1/2 and 3/4) were isolated from the fruits of Rubus idaeus L. (Rosaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses. Then chiral-phase HPLC resolution gave 1a/1b-4a/4b. Their absolute configurations were determined by comparison of the experimental ECD with the calculated data. Moreover, all isolated compounds were investigated for the neuroprotective effects against H2O2-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, and 2a (66.04%) exhibited moderate neuroprotective effects, better than trolox (60.54%) at the concentration of 25 μM.
PMID: 32502503 [PubMed - as supplied by publisher]

Source: Fitoterapia - June 1, 2020 Category: Biochemistry Authors: Lu LW, Le-Zhou, Hou ZL, Jie-Wang, Yao GD, Lin B, Huang XX, Song SJ Tags: Fitoterapia Source Type: research