Risk Factors for 90-day Readmissions With Fluid and Electrolyte Disorders Following Posterior Lumbar Fusion

Conclusion. Patients with baseline liver disease, previously diagnosed fluid and electrolyte disorders, age older than 55 years, or drug use disorders are at higher risk for readmissions with fluid and electrolyte disorders following posterior lumbar fusion. Close monitoring of fluid and electrolyte balance in the perioperative period is essential to decrease complications and reduce unplanned readmissions. Level of Evidence: 3
Source: Spine - Category: Orthopaedics Tags: EPIDEMIOLOGY Source Type: research

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CONCLUSIONS: Our initial results of active scanning PT for primary liver cancer demonstrated the feasibility, safety, and effectiveness of this advanced technique in this setting. The potential of the combination of PT with other locoregional therapies is under evaluation. PMID: 32648818 [PubMed - as supplied by publisher]
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
Publication date: Available online 11 July 2020Source: Pharmacology &TherapeuticsAuthor(s): Sergi Guixé-Muntet, Chang-Peng Zhu, Wei-Fen Xie, Jordi Gracia-Sancho
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Contributor : R D KinemanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA reduction in hepatocyte GH-signaling promotes non-alcoholic fatty liver disease (NAFLD). However, debate remains as to the relative contribution of the direct effects of GH on hepatocyte function versus indirect effects, via alterations in IGF1. To test the isolated role of hepatocyte GHR signaling, independent of changes in IGF1, we reconstituted IGF1 in mice with adult-onset, hepatocyte-specific GHR knockdown (aHepGHRkd) using a vector expressing rat IGF1 targeted specifically to hepatocytes. Compared to GHR-...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Publication date: Available online 9 July 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Yen-Ying Chen, Matthew M. Yeh
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
In the race to find a drug for the fatty liver disease NASH, George Kemble isn ’t dissuaded by Sagimet Biosciences’ size; it’s the data that count. And after pivots by the San Mateo company that Kemble heads, it has promising early data back from a mid-stage study of its drug targeting nonalcoholic steatohepatitis, or NASH, and plans to take the drug into another mid-st age study early next year. The Phase II study results come as larger companies have released promising data of their own.…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Informed consent was not required. Patient was deceased and is unidentifiable by clinical information and/or provided images.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
AbstractPurpose of ReviewHepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH) are both pulmonary vascular complications of advanced liver disease; however, these syndromes have distinct pathophysiology, clinical implications, and management.Recent FindingsWhile both conditions are associated with portal hypertension, HPS results from diffuse pulmonary capillary vasodilation and PoPH results from vasoconstriction and vascular remodeling of pulmonary arteries. In HPS, no medical therapies clearly improve outcomes; however, patients have excellent post-LT outcomes with near uniform reversal of hypoxemia. In P...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
AbstractIntroductionIn hepatitis C (HCV) patients, obesity and/or diabetes may increase the risk of liver-related outcomes. We aimed to determine whether diabetes and/or obesity are associated with adverse outcomes in direct-acting antiviral (DAA)-treated HCV patients.MethodsWe conducted a retrospective study of 33,003 HCV-infected, DAA-treated Veterans between 2013 and 2015. Body mass index was used to categorize patients into underweight (
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
AbstractBiliary atresia is a rare cholestatic liver disease that presents in infants and rapidly advances to death in the absence of intervention. As a result of blockage or destruction of the biliary tract, bile acids accumulate and drive inflammation, fibrosis, and disease progression. The standard of care, Kasai portoenterostomy (KPE), is typically performed shortly after diagnosis (currently at  ~ 2 months of age) and aims to restore bile flow and relieve cholestasis. Nevertheless, most patients continue to experience liver injury from accumulation of bile acids after KPE, since there are no known ef...
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
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