Immunodeficiency and inborn disorders of vitamin B12 and folate metabolism
Purpose of review Immune dysfunction, including severe combined immunodeficiency, has been described in genetic disorders affecting the metabolism of the vitamins cobalamin (vitamin B12) and folate. We have reviewed reports of clinical findings in patients with a number of inborn errors of cobalamin or folate metabolism, specifically looking for immune problems. Recent findings There is little evidence that immune function is affected in most of the disorders. Exceptions are Imerslund–Gräsbeck syndrome and hereditary folate malabsorption (affecting intestinal absorption of cobalamin and folate, respectively), transcobalamin deficiency (affecting transport of cobalamin in blood and cellular cobalamin uptake), and methylenetetrahydrofolate dehydrogenase 1 deficiency (catalyzing cytoplasmic interconversion of reduced folate coenzyme derivatives). Summary Although some inborn errors of cobalamin or folate can be associated with immune dysfunction, the degree and type of immune dysfunction vary with no obvious pattern.
VITAMIN B12 deficiency symptoms may develop very slowly over a long period of time, and they can be difficult to spot. You could be at risk of the deficiency if you develop any of these common signs that you may be ignoring. Should you consider adding more vitamin B12 foods to your diet?
In this study, the aim was to evaluate whether MHR was high in patients with vitamin B12 deficiency and its relationship with cardiometabolic risk factors. The study included 128 patients diagnosed with vitamin B12 deficiency and 93 healthy controls. Patients with vitamin B12 deficiency had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), MHR, C-reactive protein (CRP) and uric acid levels compared with the controls (median 139 vs 115 mmHg, p
VITAMIN B12 is credited with many important roles in the body so all hell breaks loose when you lack the vitamin. The psychiatric symptoms can be particularly acute - here's what to look for.
CONCLUSION: The diabetic neuropathy is frequent and causes severe complications. A good understanding of the underlying pathophysiology can contribute to the development of novel treatment strategies in the future. PMID: 32647958 [PubMed - as supplied by publisher]
AbstractPatients undergoing colon resection are often concerned about their functional outcomes after surgery. The primary aim of this prospective, multicentric study was to assess the intestinal activity and health-related quality-of-life (HRQL) after ileocecal valve removal. The secondary aim was to evaluate any vitamin B12 deficiency. The study included patients undergoing right colectomy, extended right colectomy and ileocecal resection for either neoplastic or benign disease. Selected items of GIQLI and EORTC QLQ-CR29 questionnaires were used to investigate intestinal activity and HRQL before and after surgery. Blood ...
VITAMIN B12 is best gained from certain foods, but certain conditions can affect a person's absorption of the vitamin or a person may lack the vitamin due to their dietary requirements. There's a sign in your chest you may be lacking vitamin B12.
Despite broad appreciation of their clinical utility, it has been unclear how vitamin B12 and folic acid (FA) function at the molecular level to directly prevent their hallmark symptoms of deficiency like anemia or birth defects. To this point, B12 and FA have largely been studied as cofactors for enzymes...
Around one-in-four people may have a vitamin B12 deficiency, according to a recent study. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
A VITAMIN B12 deficiency is more prevalent in people over the age of 50, as malabsorption issues emerge as you age. What's the sign in your fingernails that you could be lacking the vital vitamin?
ConclusionsThere is a high prevalence of vitamin B12 deficiency in infants and their mothers. There is urgent need to supplement our population with vitamin B12.