Age at onset correlate with disability in Latin American aquaporin-4-IgG-positive NMOSD patients

Publication date: Available online 2 June 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Edgar Carnero Contentti, Vanessa Daccach Marques, Ibis Soto de Castillo, Verónica Tkachuk, Pablo A. López, Juan Ignacio Rojas
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Publication date: Available online 7 July 2020Source: Diagnostic and Interventional ImagingAuthor(s): P. Roca, A. Attye, L. Colas, A. Tucholka, P. Rubini, S. Cackowski, J. Ding, J.-F. Budzik, F. Renard, S. Doyle, E.L. Barbier, I. Bousaid, R. Casey, S. Vukusic, N. Lassau, S. Verclytte, F. Cotton, OFSEP Investigators, B. Brochet, R. Casey, F. Cotton
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
Publication date: Available online 7 July 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Shuhei Nishiyama, Yoshiki Takai, Juichi Fujimori, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Abstract Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. Despite progress in the treatment of the active relapsing disease, therapeutic options targeting irreversible progressive decline remain limited. Studies using skin fibroblasts derived from patients with neurodegenerative disorders demonstrate that cell stress pathways and bioenergetics are altered when compared to healthy individuals. However, findings in MS skin fibroblasts are limited. Here, we collected skin fibroblasts from 24 healthy control in...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Conclusions: This review highlights the large variation in fall definitions, faller classifications and outcomes used in this research field. This hinders cross-comparison and pooling of data, thereby preventing researchers and clinicians from drawing conclusive findings from existing literature. The creation of an international standard for the definition of a fall, faller classification and falls outcomes would allow for transparent and coordinated falls research for people with MS, facilitating progression in this research field.Implications for rehabilitationFalls are a common occurrence among people with Multiple Scle...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Publication date: Available online 3 July 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Rasha M. Fahmi, Mahamoud El Sayed El Ebeary, Esraa M. Abd-Elrasheed, Takwa H.M. Elkhatib
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
CONCLUSIONS: No association between BMI and processing speed was found among PwMS regardless of demographic or disease-specific patient characteristics. PMID: 32619239 [PubMed - as supplied by publisher]
Source: Archives of Clinical Neuropsychology - Category: Psychiatry & Psychology Authors: Tags: Arch Clin Neuropsychol Source Type: research
The gait stability indices can potentially be used outside of a laboratory setting to measure walking characteristics related to fall history and disability level in people with multiple sclerosis.
Source: Clinical Biomechanics - Category: Orthopaedics Authors: Source Type: research
AbstractBackgroundTreatments may become redundant in older patients with multiple sclerosis (MS). Our aim was to explore whether stopping treatments might be possible in patients aged over 50 with disease inactivity.MethodsPatients over 50 were included from the population-based MS Lorraine registry if they had a relapsing –remitting course at onset and had experienced no relapse for ≥ 3 years. Patients who stopped treatments were defined as “stoppers”, and the others as “stayers”. The outcomes were the time to first relapse, to first disability progression, and to the oc...
Source: Journal of Neurology - Category: Neurology Source Type: research
Henze Santoyo-Medina Feys Goal setting is a core component of physical therapy in multiple sclerosis (MS). It is unknown whether and to what extent goals are set at different levels of the International Classification of Functioning, Disability and Health (ICF), and whether, and to which, standardized outcome measures are used in real life for evaluation at the different ICF levels. Our aim was to describe the real-world use of goal setting and outcome measures in Europe. An online cross-sectional survey, completed by 212 physical therapists (PTs) specialized in MS from 26 European countries, was conducted. Dif...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusions This analysis supports the association between CSF CHI3L1 levels and neurologic disability according to EDSS scores in patients with PPMS. Other chitinase-like proteins such as CHI3L2 may also be involved. Classification of evidence This study provides Class II evidence that CSF CHI3L1 is associated with neurologic disability in patients with PPMS.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Cerebrospinal Fluid, Multiple sclerosis, Cohort studies, Natural history studies (prognosis), Risk factors in epidemiology Article Source Type: research
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