Identification of a novel phage targeting methicillin-resistant Staphylococcus aureus In vitro and In vivo

Publication date: Available online 5 June 2020Source: Microbial PathogenesisAuthor(s): Jiawei Ji, Qian Liu, Rui Wang, Tingting Luo, Xiaokui Guo, Mengsha Xu, Qian Yin, Xuetong Wang, Min Zhou, Min Li, Ping He
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research

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Publication date: 30 August 2020Source: International Journal of Pharmaceutics, Volume 586Author(s): Heba A. Fathi, Ayat Abdelkader, Mahmoud S. AbdelKarim, Ayman A. Abdelaziz, Mohamed A. El Mokhtar, Ayat Allam, Gihan Fetih, Mahmoud El Badry, Mahmoud Elsabahy
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days. BMC Pharmacol Toxicol. 2020 Jul 08;21(1):50 Authors: Ueda T, Takesue Y, Nakajima K, Ichiki K, Ishikawa K, Takai Y, Yamada K, Tsuchida T, Otani N, Takahashi Y, Ishihara M, Takubo S, Ikeuchi H, Uchino M, Kimura T Abstract BACKGROUND: A trough concentration (Cmin) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infecti...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
In this study, a microfluidic device based on loop-mediated isothermal amplification (LAMP) was developed, which could discriminate Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, and Staphylococcus hominis and predict their methicillin resistance by targeting the mecA and femA genes within 70 min including the hands-on time. Multiplex and real-time detection was achieved in a closed system without aerosol contamination. The limits of detection (LODs) for S. aureus, S. epidermidis, S. hominis, and methicillin-resistant S. aureus (MRSA) were 20 CFU/reaction, while that for S. haemolyticus was...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 7 July 2020Source: Journal of Microbiological MethodsAuthor(s): Derick D. Jones, Lindsay K. Caesar, Chantal V. Pelzer, William J. Crandall, Christian Jenul, Daniel A. Todd, Alexander R. Horswill, Nadja B. Cech
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
A trough concentration (Cmin) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. However, sufficient clinical evidence to support t...
Source: BMC Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Research article Source Type: research
Conclusion. Our results reveal a trend towards lower MICs after positive blood culture isolates are sub-cultured. Some clinical failures among MRSA infections treated with VAN may result from this phenomenon. PMID: 32639226 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
Conclusion. One-stage exchange surgery using current techniques could improve surgical outcomes with excellent results in the management of MRSA-PJIs. PMID: 32639225 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
In conclusion, MRSA in persistent bacteremia was adapted to harsh host environment through multiple pathways involving both resistance-associated mutations and extensive gene loss.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
One current strategy to deal with the serious issue of antibiotic resistance is to use biosurfactants, weak antimicrobials in their own right, with antibiotics in order to extend the efficacy of antibiotics. Although an adjuvant effect has been observed, the underlying mechanisms are poorly understood. To investigate the nature of the antibiotic and biosurfactant interaction, we undertook a scanning electron microscopy (SEM) and atomic force microscopy (AFM) microscopic study of the effects of the tetracycline antibiotic, combined with sophorolipid and rhamnolipid biosurfactants, on Methicillin-resistant Staphylococcus aur...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
OBJECTIVES: To first describe the epidemiological data of burns, including burn types and burn-related infections, in adult and pediatric patients. Second, to determine the effect of Methicillin-Resistant Staphylococcus aureus (MRSA) on length of hospital ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
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