Transcutaneous Neuromodulation at ST36 (Zusanli) is More Effective than Transcutaneous Tibial Nerve Stimulation in Treating Constipation

This study was designed to compare the effectiveness of TN between these 2 points. Materials and Methods: Eighteen functional constipation patients (M/F: 9/9) were recruited to participate in a cross-over study with a 2-week TN at ST36 and a 2-week TN at PTN. A bowel movement diary, and the questionnaires of Patient Assessment of Constipation Symptom (PAC-SYM) and Constipation Quality of Life (PAC-QoL) were completed; anorectal manometry and spectral analysis of heart rate variability for assessing the autonomic function were performed. Results: (1) Both TN at ST36 and TN at PTN improved constipation-related symptoms (PAC-SYM scores on pre-TN vs. post-TN: 1.4±0.1 vs. 0.6±0.1 for ST36, 1.4±0.1 vs. 0.9±0.1 for PTN, both P≤0.001). (2) TN at ST36, but not TN at PTN, increased the number of weekly spontaneous bowel movements (0.9±0.2 pre-TN vs. 3.5±0.7 post-TN, P
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

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Conditions:   Constipation;   Critical Illness;   Constipation Drug Induced Interventions:   Procedure: Implementation of management pharmacological protocol of constipation;   Procedure: Implementation of bundle of prevention and non-pharmacological management Sponsor:   University of Chile Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This meta-analysis examined the efficacy and safety of peripherally acting mu-opioid receptor antagonists and other novel treatments for relieving opioid-induced constipation.Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
Authors: Morrow A, Dongarwar D, Salihu HM Abstract INTRODUCTION: Constipation is a common cause of abdominal pain in children. Prior studies have demonstrated that nearly half of the children with constipation receive enemas; however, studies regarding constipation management based on race and ethnicity have not been pursued. The goal of this investigation is to determine if demographic disparities namely, race and ethnicity and insurance status affect emergency department (ED) management of constipation and prescription of enema. METHODS: This was a retrospective cross-sectional study utilizing ED 2005-2016 da...
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Condition:   Chronic Idiopathic Constipation Interventions:   Device: Vibrant capsule;   Drug: Placebo Sponsor:   Vibrant Ltd. Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Function Constipation Intervention:   Behavioral: Lifestyle consultation Sponsor:   Second Affiliated Hospital of Xi'an Jiaotong University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Constipation Intervention:   Behavioral: Personalized dietary advice Sponsors:   Wageningen University;   Maag Lever Darm Stichting;   TNO;   Sensus;   Kellogg Company;   Bolletje;   Sonneveld;   Roquette Freres;   Nederlands Bakkerij Centrum;   Wageningen Food and Biobased Research Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Function Constipation Intervention:   Behavioral: Lifestyle consultation Sponsor:   Second Affiliated Hospital of Xi'an Jiaotong University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we examined the role of astragaloside IV in modulating mouse gut microbiota structure and the generation of SCFAs, as well as in slow transit constipation (STC). An STC model was established by treating mice with loperamide, in which the therapeutic effects of astragaloside IV were evaluated. The microbiota community structure and SCFA content were analysed by 16S rRNA gene sequencing and gas chromatography-mass spectrometry, respectively. The influence of butyrate on STC was assessed using a mouse model and Cajal cells (ICC). Astragaloside IV promoted defecation, improved intestinal mobility, suppressed ICC...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
AbstractPurposeEvaluate the impact of fecal incontinence (FI) and chronic constipation (CC) on the quality of life (QoL) in a large population and determine if a threshold of symptom scores was associated with alterations to QoL.MethodsA total of 422 outpatients with FI (n = 186), CC (n = 186), and mixed FI-CC (n = 50) referred for anorectal manometry were included prospectively. All patients completed a set of questionnaires to evaluate the severity of FI and CC (respectively Jorge and Wexner and KESS scores) and their impact on QoL (Gastrointestinal Quality of Life Index (GIQLI)).Resul...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
ConclusionsAnti-IBS syrup significantly reduced the severity of IBS symptoms compared to placebo. However, there was a need for further investigation regarding the anxiety and depression scores. (Registration No. IRCT2017061034446N1).
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
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