Yishen Huazhuo Decoction induces autophagy to promote the clearance of A β1-42 in SAMP8 mice: mechanism research of a traditional Chinese formula against Alzheimer's disease.

CONCLUSIONS: YHD could induce autophagy initiation, increase the formation of autophagosomes and autolysosome, promote the degradation of autophagy substrates, thereby to regulate autophagy, thereby to promote the clearance of Aβ1-42 to improve memory impairment in SAMP8 mice.
PMID: 32496993 [PubMed - as supplied by publisher]

Source: CNS and Neurological Disorders Drug Targets - June 3, 2020 Category: Drugs & Pharmacology Authors: Wang K, Sun W, Xu J, Qin Q, Yu Z, Cheng R, Zhang L, Liu S, Zhou Z, Zhang Y, Cui Y Tags: CNS Neurol Disord Drug Targets Source Type: research