Behavioral and structural prevention of skin cancer : Implementation and effectiveness.

CONCLUSION: Structural prevention measures in addition to behavioral measures enable a reduction of the cancer risk caused by UV radiation. The aim must be to establish these measures nationwide for the entire population. PMID: 32494842 [PubMed - as supplied by publisher]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research

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This study included advanced oral squamous cell carcinoma (OSCC) patients treated with prophylactic PBMT for OM. The site distribution of OM, OM grading (CTCAE NCI, Version 4.0, 2010), OM-related pain (VAS), analgesic protocol (WHO Analgesic Ladder), and use of enteral nutrition were evaluated weekly during treatment. Data analysis was performed using descriptive statistics expressed as median values and percentages. A total of 145 OSCC patients were included. OM most frequently affected the lateral border of the tongue (44.1%), buccal mucosa (37.2%), and labial mucosa (33.8%). Keratinized oral mucosa sites, including the ...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
ConclusionThe reported experience shows that, in selected cases, it is possible to radically remove lateral hypopharyngeal cancer with acceptable functional results.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Conclusion: The results of the present study indicated that the polymorphisms of mir ‑499 arenot associated with the risk of oral and oropharyngeal SCC in Iranian population. However, furtherlarge scale studies are needed to validate our findings.
Source: Dental Research Journal - Category: Dentistry Source Type: research
Background: Squamous cell carcinoma (SCC) is the most common cancer of the oral cavityand may be preceded by dysplastic epithelial lesion. Oral SCC (OSCC) contains a rare subset ofcancer cells with self ‑renewal ability, termed as cancer stem cells (CSCs). CD24 and CD44 as CSCmarkers are cell surface glycoproteins. These markers contribute to the onset, maintenance, andextension of tumor growth, as well as angiogenesis. In the present study, these two markers weresimultaneously evaluated to provide a specific phenotype for carcinogenesis process in oral cavity.Materials and Methods: In this analytical ‑cross‑sectiona...
Source: Dental Research Journal - Category: Dentistry Source Type: research
Anal cancer is a rare cancer with chemoradiation being the mainstay of treatment for locoregional presentation. In North America, the most common subtype is anal squamous cell carcinoma (epidermoid). A surgica...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
In this study, we determined the effects of genetic manipulation of SIRT6 in human melanoma cells,in vitro as well asin vivo. Our data demonstrated that CRISPR/Cas9 ‐mediated knockout (KO) of SIRT6 in A375 melanoma cells resulted in a significant i) decrease in growth, viability, clonogenic survival, and ii) induction of G1‐phase cell cycle arrest. Further, employing a RT2 Profiler PCR array containing 84 key transformation and tumorigenesis genes, we found that SIRT6 KO resulted in modulation of genes involved in angiogenesis, apoptosis, cellular senescence, epithelial ‐to‐mesenchymal transition, hypoxia signaling...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
Basal cell carcinoma (BCC) is the most common skin cancer, and its incidence rate is increasing [1]. BCC characteristically arises in body parts that are exposed to the sun and is most common on the head and neck (80%), followed by the trunk (15%), and the arms and legs [2]. Since BCC has low metastatic potential, treatment focuses on local control.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
In conclusion, the immunophenotypes of peSCC were of great value in predicting LNM and prognosis, and may provide support for clinical stratification management and immunotherapy intervention.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
CONCLUSION: DNA methylation is a source of efficient prognostic blood plasma- and tissue-based biomarkers. However, prior to clinical implementation, studies must prove that biomarker-guided treatment selection can lead to better outcomes or reduced toxicity. The applicability of DNA methylation as a predictive biomarker for targeted drug-based cancer therapy seems promising, although further validation is needed. PMID: 32613323 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Conclusions: In this study, the conversion of maintenance immunosuppression from calcineurin inhibitors to mTOR inhibitors for clinical indications did appear to reduce the incidence of NMSC in kidney and liver transplant recipients. PMID: 32605413 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
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