Importance of standardizing the number of cells measured for coefficient of variation (COV) estimates of corneal endothelial cell area values as relevant to contact lens wear

The corneal endothelium is a single layer of cells on the posterior (inner) surface of the cornea. For a normal healthy eye in human adults, the cells that form this monolayer are remarkable in appearance in that they are relatively constant in size and shape, and sometimes considered to have a resemblance to a uniform hexagonal pattern [1,2]. However, even in early clinical studies in the 1980 ′s, it was reported that this was not always the case with some endothelia being transformed into a mixture of smaller and larger cells with many of them no longer having the distinct ‘hexagonal’ shape [3–5].

Source: Contact Lens and Anterior Eye - June 4, 2020 Category: Opthalmology Authors: Michael J. Doughty Source Type: research