Antidepressant Prescribing and Suicide/Self-Harm by Young Australians: Regulatory Warnings, Contradictory Advice, and Long-Term Trends

In 2004, the US Food and Drug Administration (FDA) controversially issued a black box warning that antidepressants were associated with an increased risk of suicidal thoughts and behaviours in people aged under 18 years. In 2007, the warning was expanded to include young adults aged under 25 years. In 2005, the Australian Therapeutic Goods Administration responded to the FDA warning by requiring Product and Consumer Information leaflets to be updated to reflect the risk. However, there was considerable debate, and at times emotive backlash, in academic journals and the international media. Prominent US and Australian mental health organisations and psychiatrists challenged the FDA warning. They argued that, on balance, antidepressant use was likely to reduce the risk of suicide. Several ecological studies were cited misleadingly as evidence that decreasing antidepressant use increases suicide risk. From 2008 to 2018, Australian per-capita child, adolescent and young adult antidepressant dispensing (0–27 years of age) and suicide (0–24 years) rates have increased approximately 66% and 49%, respectively. In addition, there was a 98% increase in intentional poisonings among 5 to 19 year-olds in New South Wales and Victoria between 2006 and 2016, with substantial overlap between the most commonly dispensed psychotropics and the drugs most commonly used in self-poisoning. These results do not support claims that increased antidepressant use reduces youth suicide risk. ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

Related Links:

Studies have been coming out focusing on the biological markers of suicide. Here, we present two cases with raised C-reactive protein who were admitted after attempts of suicide by overdose. There is a need to study the neuro-immuno-endocrinal changes in s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Poisoning Source Type: news
Fatal sodium nitrite poisonings are unusual in the forensic setting. Suicide by poisoning includes drug overdose, the inhalation of toxic gasses, and poisoning from pesticides and chemical substances. Sodium nitrite is an inorganic compound usually seen as...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Poisoning Source Type: news
An overdose of isoniazid (INH) is potentially fatal and attempts at suicide are very rare in children. Three patients aged 14-17  years who were receiving INH for tuberculosis prophylaxis were admitted to the emergency department with generalised tonic-clo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Poisoning Source Type: news
Although James Toussaint has never had COVID-19, the pandemic is taking a profound toll on his health. First, the 57-year-old lost his job delivering parts for a New Orleans auto dealership in spring 2020, when the local economy shut down. Then, he fell behind on his rent. Last month, Toussaint was forced out of his apartment when his landlord—who refused to accept federally funded rental assistance—found a loophole in the federal ban on evictions. Toussaint has recently had trouble controlling his blood pressure. Arthritis in his back and knees prevents him from lifting more than 20 pounds, a huge obstacle for...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
This study included 2018 data from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project (HCUP) to determine the prevalence of selected nonfatal injuries among older adults treated in emergency departments (EDs) and hospitals. Injury mechanisms among the leading causes of injury death in older adults were studied, including unintentional falls, unintentional traffic-related motor vehicle crashes, unintentional opioid overdoses, and self-harm (suicidal and nonsuicidal by any mechanism). In 2018, an estimated 2.4 million ED visits and>700,000 hospitalizations from these injuries occurred...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Source Type: research
Critical care providers frequently care for patients who are poisoned under a variety of circumstances and develop a wide range of clinical syndromes. Poisonings may be intentional (eg, suicide, homicide) or unintentional (eg, recreational abuse, medication error). They may involve over-the-counter medications, prescribed outpatient drugs, inpatient drug regimens, illicit substances, or environmental exposures. In the United States, deaths from overdoses reached 70,630 in 2019.1 Exposures with more serious outcomes (moderate, major, or death) increased 4.61% per year since 2000.
Source: Critical Care Clinics - Category: Intensive Care Authors: Tags: Preface Source Type: research
OBJECTIVES: To describe trends in abuse, misuse, and suicide attempts involving diphenhydramine (DPH). METHODS: We analyzed intentional DPH exposures of individuals ≥10 years old reported to U.S. Poison Control Centers using data from the Natio...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Cochrane authors have reviewed the international literature regarding pharmacological (drug) and natural product (dietary supplementation) treatment trials in the field. A total of seven trials that met inclusion criteria were identified. There is little evidence of beneficial effects of either pharmacological or natural product treatments. However, few trials have been conducted and those that have are small, meaning that possible beneficial effects of some therapies cannot be ruled out. Why is this review important?Self ‐harm (SH), which includes intentional self‐poisoning/overdose and self‐injury, is a major ...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
CONCLUSIONS: The risk factors for suicide in our sample of doctors overlap with data from literature for doctors in western countries. Clinical recommendations and prevention strategies for suicide risk are therefore similar. PMID: 33349717 [PubMed - in process]
Source: Rivista di Psichiatria - Category: Psychiatry Tags: Riv Psichiatr Source Type: research
Authors: Shklovsky-Kordi A, Gelernter R, Berkovitch M, Dagan Z, Kozer E Abstract BACKGROUND: Acetaminophen is the most common drug involved in pediatric poisonings, both intentionally and accidentally, and is the leading cause of acute liver failure among all age groups. OBJECTIVES: To define the characteristics of patients admitted to a pediatric emergency department (ED) where serum acetaminophen concentrations were measured, and to determine which variables are associated with significant risk of acetaminophen toxicity. METHODS: Acetaminophen serum concentrations were measured, in a retrospective case se...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
More News: Academia | Australia Health | Children | Depression | Food and Drug Administration (FDA) | Marketing | Men | Overdose | Poisoning | Psychiatry | Study | Suicide | Wales Health | Warnings