Glucose fluctuations promote vascular BK channels dysfunction via PKC α/NF-κB/MuRF1 signaling

Glucose fluctuations may contribute to large conductance calcium activated potassium (BK) channel dysfunction. However, the underlying mechanisms remain elusive. The aim of this study was to investigate the molecular mechanisms involved in BK channel dysfunction as a result of glucose fluctuations. A rat diabetic model was established through the injection of streptozotocin. Glucose fluctuations in diabetic rats were induced via consumption and starvation. Rat coronary arteries were isolated and coronary vascular tensions were measured after three weeks.

Source: Journal of Molecular and Cellular Cardiology - June 4, 2020 Category: Cytology Authors: Zhen-Ye Zhang, Ling-Ling Qian, Ning Wang, Ling-Feng Miao, Xin Ma, Shi-Peng Dang, Ying Wu, Xiao-Yu Liu, Xiao-Yan Li, Qiang Chai, Min Pan, Fu Yi, Tian-You Ling, Ru-Xing Wang Source Type: research