Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons

ConclusionsOur study points to modest and context-dependent transcriptional consequences ofMbd5 disruption in the brain. It also suggests a possible link betweenMBD5 and perturbations in ciliary function, which is an established pathogenic mechanism in developmental disorders and syndromes.

Source: Molecular Autism - June 4, 2020 Category: Molecular Biology Source Type: research