Patient-specific Conditional Joint Models of Shape, Image Features and Clinical Indicators.
Patient-specific Conditional Joint Models of Shape, Image Features and Clinical Indicators. Med Image Comput Comput Assist Interv. 2019 Oct;11767:93-101 Authors: Egger B, Schirmer MD, Dubost F, Nardin MJ, Rost NS, Golland P Abstract We propose and demonstrate a joint model of anatomical shapes, image features and clinical indicators for statistical shape modeling and medical image analysis. The key idea is to employ a copula model to separate the joint dependency structure from the marginal distributions of variables of interest. This separation provides flexibility on the assumptions made during the modeling process. The proposed method can handle binary, discrete, ordinal and continuous variables. We demonstrate a simple and efficient way to include binary, discrete and ordinal variables into the modeling. We build Bayesian conditional models based on observed partial clinical indicators, features or shape based on Gaussian processes capturing the dependency structure. We apply the proposed method on a stroke dataset to jointly model the shape of the lateral ventricles, the spatial distribution of the white matter hyperintensity associated with periventricular white matter disease, and clinical indicators. The proposed method yields interpretable joint models for data exploration and patient-specific statistical shape models for medical image analysis. PMID: 32494781 [PubMed]
Condition: Stroke Intervention: Device: T-chair Sponsor: KU Leuven Not yet recruiting
Conditions: Cerebral Cavernous Malformation; Cavernous Angioma; Hemorrhagic Microangiopathy Intervention: Other: observational Sponsors: University of Chicago; Mayo Clinic; University of California, San Francisco; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
Conditions: Amyotrophic Lateral Sclerosis; Brainstem Stroke; Muscular Dystrophies; Parkinson's Disease and Parkinsonism; Multiple System Atrophy; Brain Tumor Adult; Spinal Cord Injuries; Locked-in Syndrome Interventions: Behavioral: BCI-FIT multi-modal access; Behavioral: BCI-FIT adaptive signal modeling; Behavioral: BCI-FIT active querying; Behavioral: BCI-FIT language modeling Sponsor: Oregon H...
Conditions: Stroke; Subluxation, Glenohumeral Intervention: Device: kinesiotape Sponsors: Ankara Physical Medicine and Rehabilitation Education and Research Hospital; Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Completed
A guide on restoration and recovery following a period of rapid change along the whole patient pathway; and an implementation guide for adapting acute services during the pandemic.
CONCLUSION: Physical and mental health functioning declined among symptomatic individuals and those with stroke/TIA history. Thus, frequent monitoring for the early detection of stroke symptoms may be recommended. PMID: 32653213 [PubMed - as supplied by publisher]
Authors: Baud JM, Stanciu D, Yeung J, Maurizot A, Chabay S, de Malherbe M, Chadenat ML, Bachelet D, Pico F Abstract INTRODUCTION: Carotid atherosclerosis represents 8 to 15% of ischemic strokes in relation to the concept of "vulnerable" plaque. Contrast enhanced ultrasound (CEUS) can detect moving microbubbles within the plaque corresponding to neovessels that constitute "precursors" of vulnerable plaque and intraplaque hemorrhage. CEUS was not studied specifically in acute ischemic strokes. The aim of this study is to analyse the prevalence of CEUS carotid plaque ipsilateral at the ischemic str...
AbstractIntracerebral hemorrhage (ICH) is a non-traumatic cerebrovascular disorder with very high morbidity and mortality and regarded as one of the deadliest stroke subtypes. Notably, there is no effective treatment for ICH. Despite an overall increase in preclinical studies, the pathophysiology of ICH is complex and remains enigmatic. To this end, ICH was induced in male CD-1 mice and the ipsilateral brain tissue was characterized in an unbiased manner using a combination of proteomics and bioinformatics approaches. A total of 4833 proteins were revealed by quantitative proteomic analysis. Of those, 207 proteins ex...
CONCLUSIONS: D-ER at either a 7.5 mg or 10 mg dose did not significantly increase performance on the 2 MinWT in stroke survivors with gait impairment, although this study was terminated early before full enrollment. (Clinical Trial # NCT02271217). PMID: 32651338 [PubMed - as supplied by publisher]
DiscussionThe protocol outlines the methods for systematically reviewing and synthesising evidence of screening strategies for type 2 diabetes mellitus and their effect on health outcomes associated with the disease. The potential impact of this systematic review is improved evidence-informed decision-making for policies and practice for screening of type-2 diabetes.Systematic review registrationPROSPERO CRD42020147439