IJERPH, Vol. 17, Pages 4024: The Relation between Persistent Post-Traumatic Headache and PTSD: Similarities and Possible Differences

IJERPH, Vol. 17, Pages 4024: The Relation between Persistent Post-Traumatic Headache and PTSD: Similarities and Possible Differences International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17114024 Authors: Martina Guglielmetti Gianluca Serafini Mario Amore Paolo Martelletti Post-traumatic headache (PTH) may be considered a secondary headache, which is linked to severe disability and psychosocial impairment. Interestingly, nearly 30% of subjects with persistent post-traumatic headache (PPTH) also suffer from post-traumatic stress disorder (PTSD). Although existing studies demonstrated the existence of common pathophysiological characteristics in subjects with migraine and PPTH, the differences and similarities between these complex diseases are currently poorly understood and are yet to be comprehensively elucidated. Thus, the present review aimed to systematically investigate the nature of PPTH in the effort to better identify both the neurobiological and clinical aspects underlying this condition. Overall, the included studies reported that: (1) the predictors for persistent acute traumatic injury to the head were female gender, persistent symptoms related to mild post-traumatic brain injury (mTBI), PTSD, elevated inflammatory markers, prior mild traumatic brain injury, being injured while suffering from alcohol abuse; (2) static/dynamic functional connectivity differences, white matter tract abnormalities, and morphology changes w...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research