Trolox is More Successful than Allopurinol to Reduce Degenerative Effects of Testicular Ischemia/Reperfusion Injury in Rats
Reperfusion surgery following testicular ischemia is a reproductive health threatening status and may result with organ dysfunction in men. The high level of reactive oxygen species (ROS) and cease of blood flow to the testis is the most important cause of this ailment. Until today, numerous experimental studies reported that antioxidants might be efficient to alleviate oxidative stress induced organ dysfunction. For this purpose, in this study, we have investigated the protective effects of xanthine oxidase (XO) inhibitor, allopurinol, and ROS scavenger, trolox, in a comparative perspective in testicular ischemia reperfusion injury subjected rats.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Ugur Seker, Yusuf Nergiz, Ayfer Aktas, Murat Akkus, M. Ferit Ozmen, Emre Uyar, Sevda Soker Source Type: research