AD-NET: Age-adjust neural network for improved MCI to AD conversion prediction

Publication date: Available online 1 June 2020Source: NeuroImage: ClinicalAuthor(s): Fei Gao, Hyunsoo Yoon, Yanzhe Xu, Dhruman Goradia, Ji Luo, Teresa Wu, Yi Su, for the Alzheimer's Disease Neuroimaging Initiative
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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Abstract To evaluate functional capacity, mobility and balance in elderly patients with Alzheimer's Disease (AD), in its mild, moderate and severe forms, verifying the existence of correlation among these parameters. Eighty-eight elderly patients (81.79 ± 6.54 years) diagnosed with AD treated at an elderly care reference center in Taguatinga-DF were selected, and information was collected between November 2018 and March 2019. Data collection was initially made by filling in the evaluation form. Subsequently, two questionnaires were administered to caregivers (Clinical Dementia Rating-CDR and Disability Assessment fo...
Source: Revista Brasileira de Cineantropometria e Desempenho Humano - Category: Sports Medicine Source Type: research
Conditions:   Preclinical Alzheimer's Disease;   Early Alzheimer's Disease Interventions:   Drug: BAN2401;   Drug: Placebo Sponsors:   Eisai Inc.;   Alzheimer’s Clinical Trial Consortium (ACTC);   Biogen;   National Institute on Aging (NIA) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Alzheimer Disease;   Mild Cognitive Impairment Interventions:   Drug: Flortaucipir F18;   Procedure: Brain PET scan Sponsor:   Avid Radiopharmaceuticals Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those workin...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Genome-wide association studies identified theBIN1 locus as a leading modulator of genetic risk in Alzheimer's disease (AD). One limitation in understandingBIN1's contribution to AD is its unknown function in the brain. AD-associatedBIN1 variants are generally noncoding and likely change expression. Here, we determined the effects of increasing expression of the major neuronal isoform of human BIN1 in cultured rat hippocampal neurons. Higher BIN1 induced network hyperexcitability on multielectrode arrays, increased frequency of synaptic transmission, and elevated calcium transients, indicating that increasing BIN1 drives g...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
Molecules, Vol. 25, Pages 3190: Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy Molecules doi: 10.3390/molecules25143190 Authors: Lazhar Zribi Irene Pachòn-Angona Òscar M. Bautista-Aguilera Daniel Diez-Iriepa José Marco-Contelles Lhassane Ismaili Isabel Iriepa Fakher Chabchoub Alzheimer’s disease (AD) is multifactorial disease characterized by the accumulation of abnormal extracellular deposits of amyloid-beta (Aβ) peptide, and intracellular neurofibrillary tangles (NFTs), along with dramatic neurona...
Source: Molecules - Category: Chemistry Authors: Tags: Communication Source Type: research
This article aims to alert the medical community and public health authorities to accumulating evidence on health benefits from sun exposure, which suggests that insufficient sun exposure is a significant public health problem. Studies in the past decade indicate that insufficient sun exposure may be responsible for 340,000 deaths in the United States and 480,000 deaths in Europe per year, and an increased incidence of breast cancer, colorectal cancer, hypertension, cardiovascular disease, metabolic syndrome, multiple sclerosis, Alzheimer’s disease, autism, asthma, type 1 diabetes and myopia. Vitamin D has long b...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Publication date: Available online 11 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Chen Fang, Chunfei Li, Parisa Forouzannezhad, Mercedes Cabrerizo, Rosie E. Curiel, David Loewenstein, Ranjan Duara, Malek Adjouadi, for the Alzheimer's Disease Neuroimaging Initiative
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Conclusion: These results indicate that miR-376a-3p and miR-598-3p were related to cognitive impairment after hearing loss. PMID: 32646202 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
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