The probiotic Lactobacillus coryniformis CECT5711 reduces vascular pro-oxydant and pro-inflammatory status in obese mice

Obesity is associated with intestine dysbiosis, and characterized by a low grade inflammatory status, which affects vascular function. In the present study we evaluated the effects of a probiotic with immunomodulatory properties, Lactobacillus coryniformis CECT5711, in obese mice fed a high fat diet (HFD). The probiotic treatment was given for 12 weeks, and it did not affect the weight evolution, although it reduced basal glycemia and insulin resistance. L. coryniformis administration to HFD-induced obese mice induced marked changes in microbiota composition and reduced the metabolic endotoxemia since it decreased the lipopolysaccharide (LPS) plasma level, which was associated with a significant improvement of the gut barrier disruption. Furthermore, it lowered tumor necrosis factor-α expression in liver, improving the inflammatory status and thus the glucose metabolism. Additionally, the probiotic reversed the endothelial dysfunction observed in obese mice when the endothelium- and nitric oxide-dependent vasodilatation induced by acetylcholine in aortic rings was studied. It also restored the increased vessel superoxide levels observed in obese mice, by reducing NADPH oxidase activity and increasing antioxidant enzymes. Moreover, chronic probiotic administration for 2 weeks also improved endothelial dysfunction, and vascular oxidative stress induced by in vivo administration of LPS in control mice received standard chow diet. The current study demonstrates an endothel...
Source: Clinical Science - Category: Biomedical Science Authors: Source Type: research