Sosei Heptares Notes Phase IIIb ARGON Study With Enerzair(R) Breezhaler(R) (QVM149) Meets Primary Endpoint in Patients With Uncontrolled Asthma

Once-daily Enerzair® Breezhaler® (QVM149; IND/GLY/MF) met primary endpoint, demonstrating non-inferiority to a free combination of twice-daily Sal/Flu plus once-daily Tio in improving quality of life in people with uncontrolled asthma1 IND/GLY/M... Biopharmaceuticals, Drug Delivery Sosei Heptares, Novartis, Enerzair, Breezhaler, asthma
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

Related Links:

' It has an earlier age of onset, usually in infancy, and can occur with the atopic triad that presents with asthma and seasonal allergies as well. 'Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Dermatology News Source Type: news
Authors: Joo SH, Hyun KJ, Kim YH Abstract Objectives: We evaluated the usefulness of the standardized nasal provocation test (NPT) protocol published recently by the European Academy of Allergy, Asthma and Immunology (EAACI) and compared the utility of several parameters for diagnosing allergic rhinitis (AR) caused by house dust mite (HDM). Subjective parameters were nasal and ocular symptoms measured using the visual analogue scale (VAS), and objective parameters were peak nasal inspiratory flow (PNIF), minimal cross-sectional area (MCA), and total nasal volume (TNV). Methods: Before and after spraying Dermato...
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
Authors: Chen LX, Xu CM, Gao F, Zhu MF, Xu MJ, Zhang JR, Qian WX Abstract OBJECTIVE: To explore the associations of interleukin-18 (IL-18) and IL-9 gene polymorphisms with susceptibility to asthma, and to study the associations between IL-18 and IL-9 expression levels and polymorphisms. PATIENTS AND METHODS: A total of 200 asthma patients in our hospital were collected as disease group, while 200 healthy people were taken as control group. The deoxyribonucleic acid (DNA) was extracted from peripheral blood and sent to the company for the detection of IL-18 and IL-9 gene polymorphisms via sequencing. The levels ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Anaphylaxis is a severe allergic reaction that can potentially lead to death if not promptly treated. Allergic reactions typically begin suddenly after exposure to an allergen, which may be a food, medication, insect sting, or another trigger. Anaphylaxis can occur in anyone at any time; it can sometimes be triggered by allergens that a person has only had mild reactions to in the past — or to which they have never reacted to before. Recognizing anaphylaxis A mild allergic reaction may consist of hives, itching, flushing, swelling of the lips or tongue, or some combination of these. However, throat swelling or tighte...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Emergency Planning Source Type: blogs
Publication date: 7 July 2020Source: Cell Reports, Volume 32, Issue 1Author(s): Nathan D. Jackson, Jamie L. Everman, Maurizio Chioccioli, Luigi Feriani, Katherine C. Goldfarbmuren, Satria P. Sajuthi, Cydney L. Rios, Roger Powell, Michael Armstrong, Joe Gomez, Cole Michel, Celeste Eng, Sam S. Oh, Jose Rodriguez-Santana, Pietro Cicuta, Nichole Reisdorph, Esteban G. Burchard, Max A. Seibold
Source: Cell Reports - Category: Cytology Source Type: research
AbstractPurpose of ReviewIn the ever-changing healthcare system, along with new advancements in the field of allergy, the workflow for the allergist continues to evolve requiring more time spent doing non-clinical duties such as documentation and reviewing reimbursement challenges in the midst of busy clinics. The use of electronic medical records and medical scribes has emerged as tactics to aid the clinic ’s workflow and efficiency in the modern allergy and immunology clinic.Recent FindingsThe practicing allergist can implement various additional strategies in their office workflow to maximize and synthesize good m...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewThe most serious DNA damage, DNA double strand breaks (DNA-dsb), leads to mutagenesis, carcinogenesis or apoptosis if left unrepaired. Non-homologous end joining (NHEJ) is the principle repair pathway employed by mammalian cells to repair DNA-dsb. Several proteins are involved in this pathway, defects in which can lead to human disease. This review updates on the most recent information available for the specific diseases associated with the pathway.Recent FindingsA new member of the NHEJ pathway, PAXX, has been identified, although no human disease has been associated with it. The clinical phenoty...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
The objective of this review is to summarize the various clinical manifestations of localized disease in GPA and their treatment.Recent FindingsSinonasal disease is seen in up to 90% of patients. Otologic and ocular involvement is also commonly seen. Laryngeal and tracheal disease although less common is associated with significant morbidity and can be therapeutically challenging. Clinicians need to be aware of these localized GPA manifestations as they may be presenting disease features in the absence of other systemic findings. Treatment of localized GPA involves both immunosuppressive and surgical interventions for spec...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewOlfactory functioning disturbances are common following traumatic brain injury (TBI) having a significant impact on quality of life. A spontaneous recovery of the olfactory function over time may occur in TBI patients. Although there is no standard treatment for patients with posttraumatic olfactory loss, olfactory training (OT) has shown some promise beneficial effects. However, the mechanisms underlying spontaneous recovery and olfactory improvement induced by OT are not completely known.Recent FindingsThe spontaneous recovery of the olfactory function and the improvement of olfactory function af...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewEustachian tube dysfunction (ETD) presents with symptoms of aural fullness and pressure, muffled hearing, tinnitus, and otalgia. When severe, it can lead to many common ear disorders such as otitis media with effusion, tympanic membrane retraction/perforation, and cholesteatoma. These diseases are prevalent in both the pediatric and adult population and significantly impact quality of life. The pathophysiology of ETD in the absence of an obstructive lesion has long been debated but is thought to be related to functional obstruction (i.e., inefficient tensor veli palatini muscle) and/or nasal cavity...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
More News: Asthma | Pharmaceuticals | Study