Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes

Conclusions/interpretationOur study identifies increased responsiveness to IFN-1 as a feature of both the NOD mouse model of autoimmune diabetes and human established type 1 diabetes. A stimulated IFN-1 gene signature may be a potential biomarker for type 1 diabetes and used to evaluate the effects of therapies targeting this pathway.Data availabilityMouse gene expression data are found in the gene expression omnibus (GEO) repository, accession GSE146452 (www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE146452). Nanostring count data from the human experiments were deposited in the GEO repository, accession GSE146338 (www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE146338). Data files and R code for all analyses are available athttps://github.com/rodriguesk/T1D_truculture_diabetologia.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research