Cancers, Vol. 12, Pages 1477: Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer

Cancers, Vol. 12, Pages 1477: Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers12061477 Authors: Assunta Sellitto Ylenia D’Agostino Elena Alexandrova Jessica Lamberti Giovanni Pecoraro Domenico Memoli Domenico Rocco Elena Coviello Giorgio Giurato Giovanni Nassa Roberta Tarallo Alessandro Weisz Francesca Rizzo Estrogen receptors (ERα and ERβ) are ligand-activated transcription factors that play different roles in gene regulation and show both overlapping and specific tissue distribution patterns. ERβ, contrary to the oncogenic ERα, has been shown to act as an oncosuppressor in several instances. However, while the tumor-promoting actions of ERα are well-known, the exact role of ERβ in carcinogenesis and tumor progression is not yet fully understood. Indeed, to date, highly variable and even opposite effects have been ascribed to ERβ in cancer, including for example both proliferative and growth-inhibitory actions. Recently ERβ has been proposed as a potential target for cancer therapy, since it is expressed in a variety of breast cancers (BCs), including triple-negative ones (TNBCs). Because of the dependence of TNBCs on active cellular signaling, numerous studies have attempted to unravel the mechanism(s) behind ERβ-regulated gene expression programs but the scenario...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research