Pharmacotherapy for Borderline Personality Disorder: an Update of Published, Unpublished and Ongoing Studies

AbstractPurpose of the ReviewWe aim to identify the most recent evidence of randomised controlled trials evaluating continued drug treatments in people with a diagnosis of BPD, review the most recent findings, highlight trends in terms of currently ongoing studies and comment on the overall body of evidence.Recent FindingsWe identified seven new RCTs, plus newly available data for an older RCT. Only three of these RCTs have been published in full text, while we found study data posted at trial registry platforms for the others.SummaryThe new findings do not support fluoxetine as a treatment option for suicide and self-harm prevention. A large effectiveness study did not detect beneficial effects of lamotrigine in routine care. The prevalent use of medications in BPD is still not reflected or supported by the current evidence. More research is needed regarding the most commonly used substances and substance classes, i.e. SSRIs, and quetiapine, but also with respect to people presenting with distinct comorbid conditions.
Source: Current Psychiatry Reports - Category: Psychiatry Source Type: research

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Has anyone else noticed that clinicians seem to be assuming that chronic suicidality equals a definitive diagnosis of BPD more and more, without doing a good differential? I mean, with chronic suicidality, BPD should definitely be on the differential list, but it's not the only disorder that can lead to this (MDD, Persistent Depressive Disorder, PTSD, etc), nor is it sufficient to diagnosis BPD in and of itself. It remains me of the old (and still somewhat prevalent) idea that non-suicidal... Borderline Personality Disorder as a "dumping ground" diagnosis for chronic suicidality?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
Building on existing literature, the authors draw the landscape of psychiatric emergencies, and focus on borderline personality disorder, frequently encountered, and strongly linked to death by suicide. A review of knowledge in terms of diagnosis, prognosi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Authors: Besch V, Debbané M, Greiner C, Magnin C, De Néris M, Ambrosetti J, Perroud N, Poulet E, Prada P Abstract Building on existing literature, the authors draw the landscape of psychiatric emergencies, and focus on borderline personality disorder, frequently encountered, and strongly linked to death by suicide. A review of knowledge in terms of diagnosis, prognosis, etiology, and treatment, as well as their own experiences, lead them to propose areas of progress that would secure the patient's care pathway. The evolution of society has led psychiatric emergency departments to play the role of a sa...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
Self-harm is considered a pervasive problem in several psychopathologies, and especially in Borderline Personality Disorder (BPD). Self-harming behaviors may be enacted for many purposes for example to regulate emotions and to reduce dissociation. BPD pati...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
OBJECTIVES: Borderline personality disorder is a complex mental disorder that is associated with a high degree of suffering for the individual. Dialectical behaviour therapy has been studied in the largest number of controlled trials for treatment of indiv...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Program and Other Evaluations, Effectiveness Studies Source Type: news
Conclusions: In treatment-seeking SUD patients, comorbid ADHD is associated with polysubstance dependence, psychopathological complexity, and social risks, which substantiates the clinical relevance of screening, diagnosing, and treating ADHD in patients with SUDs.Eur Addict Res
Source: European Addiction Research - Category: Addiction Source Type: research
CONCLUSION: This research adds to the accumulating body of knowledge of psychotherapeutic treatment of borderline personality disorder and supports the use of both dialectical behaviour therapy and conversational model as effective treatments in routine clinical settings, with some additional benefits for dialectical behaviour therapy for persons with co-morbid depression. PMID: 32551819 [PubMed - as supplied by publisher]
Source: The Australian and New Zealand Journal of Psychiatry - Category: Psychiatry Authors: Tags: Aust N Z J Psychiatry Source Type: research
Posttraumatic Stress Disorder (PTSD) is defined as a fear-based disorder with several features necessary for a formal diagnosis which include: avoidance behaviors, re-experiencing, increased arousal and negative affect and/or cognition.1 Avoidance behaviors may include avoiding people, places or situations that could be emotionally ‘triggering’ of a traumatic event. For example, some veterans may avoid amusement parks or festivities that have fireworks or excessive noise as it may cause flashbacks or anxiety. Re-experiencing behaviors often include emotional flashbacks, intrusive thoughts or nightmares. Someon...
Source: Psych Central - Category: Psychiatry Authors: Tags: Borderline Personality PTSD Relationships & Love Trauma Avoidance Borderline Personality Disorder C-PTSD complex trauma Emotional Dysregulation Source Type: news
Authors: CichoĊ„ L, Janas-Kozik M, Siwiec A, Rybakowski JK Abstract Bipolar disorder (BD) is characterized by pathological changes in mood as well as recurring episodes of mania, hypomania, depression and mixed symptoms. In recent years, the number of BD diagnoses has risen considerably in children and adolescents. Itis believed that anaverage rate of prevalence of bipolar spectrum disorder in the pediatric population is 1.8%, and BD type I - 1.2%, and the prevalence of the disorder increases with the age of patients. Despite the same diagnostic criteria, there are premises that suggest thatthe symptoms of the diso...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
ConclusionsThe findings of our meta-analysis indicate that, overall, currently available treatments are effective in treating self-harm, suicidal ideation, and depressive symptoms in adolescence. Although the treatment intervention conditions showed only small to moderate effects in comparison to active controls, these differences were statistically significant and are clinically important. Further research is needed to understand the reduction in self-harm within active controls, which may arise due to the natural course of self-harm, or the potential efficacy of treatment as usual and enhanced usual care. Given the signi...
Source: Borderline Personality Disorder and Emotion Dysregulation - Category: Psychiatry Source Type: research
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