Tuning activation and self-immolative properties of the bioorthogonal alkene-azide click-and-release strategy

We report on a series of 4-azidobenzyloxy-substituted self-immolative linkers which undergo [3+2]-cycloaddition (click reaction) with functionalized trans-cyclooctenes (TCOs) at second-order rate constants in the range of 0.017 to 4.9 M-1s-1.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research