Diabetic Nephropathy and Proximal Tubular Damage

Diabetic nephropathy (DN) is a major cause of uremia in developed societies. Inflammation is emerging as an important mechanism for its pathogenesis and progression. Herein, we review 4 recently described cellular receptors that have been shown to mediate diabetic interstitial kidney disease. Peroxisome proliferator-activated receptor-γ attenuates STAT-1 activation and has shown promise in renoprotection. Its clinical utility is limited mainly by fluid retention through upregulation of sodium–hydrogen exchanger-3 and aquaporin-1 channels in the proximal tubule.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: ICURT PROCEEDINGS Source Type: research

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Abstract Long non-coding RNAs (lncRNAs) are implicated in various cellular and pathological processes. Two lncRNAs, myocardial infarction-associated transcript (MIAT) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), may be involved in the pathogenesis of coronary artery disease (CAD). Here, we aimed to determine the relative circulating levels of MIAT and MALAT1 in 110 stable CAD patients and 117 controls and to correlate their levels with the clinical and laboratory data. Peripheral blood expression levels were quantified by Real-Time qPCR. The median MIAT expression level in CAD patients was significa...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Am I allowed to post the whole article here (for those facing a paywall? Ive posted a portion of it): To Drive Down Insulin Prices, W.H.O. Will Certify Generic Versions About 80 million people with diabetes around the world need the hormone, and half of them can’t afford it. Creating competition could help, the agency said. www.nytimes.com In Today's NYT: GLOBAL HEALTH To Drive Down Insulin Prices, W.H.O. Will Certify Generic Versions "About 80 million people with diabe...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
Resumo Contexto As infec ções profundas de extremidades representam um desafio para o salvamento de membro dos pacientes. Objetivos Investigar se existe concordância entre as culturas de osso e tecido profundo em pacientes com lesões tróficas de extremidades. Métodos Foi realizado um estudo retrospectivo incluindo 5 4 pacientes com lesões tróficas profundas de extremidades internados, no Complexo Hospitalar Universitário Professor Edgard Santos, Salvador (BA), Brasil. Foram incluídos todos os pacientes que realizaram culturas de lesões trófi...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
This study not only sheds light on the mechanisms that underlie human endocrine cell differentiation, but also has important implications for devising improved protocols for producing replacement beta cells for diabetes cell therapy.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Conclusions Accelerometer-determined MVPA may provide more consistent risk estimates for incident diabetes than self-reported MVPA.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: EPIDEMIOLOGY Source Type: research
DISCUSSION: ED utilization after outpatient hand surgery is low, with postoperative pain being the most common cause of an ED visit at all time points. Nearly 98% of patients presenting to the ED for postoperative pain are subsequently discharged home. LEVEL OF EVIDENCE: Level III, Retrospective Cohort. PMID: 31714419 [PubMed - as supplied by publisher]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
ConclusionFracture blisters cannot be assumed to be sterile with more than 10% of our sample being colonized. Blister rupture during surgery or prepping for surgery could represent a contamination of the sterile field. No risk factors were significantly associated with colonization in our sample. However, colonized aspirates may not predispose patients to increased infection rates.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Publication date: Available online 13 November 2019Source: Journal of Functional FoodsAuthor(s): Lei Chen, Xiujun Lin, Hui TengAbstractLow bioavailability of dihydromyricetin (DMY) affects its in vivo bioactivity. O/W-based microemulsions of DMY (S-DMY) were established and IR-induced HepG2 cells were conducted to investigate the effect of S-DMY on glucose metabolism in the present study. It was observed that the bioaccessibility of DMY increased treblein emulsified form, as assessed by Caco-2 cell models. We also found that both S-DMY and DMY increased the glucose consumption of insulin resistant cells, and elevated the l...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 14 November 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): The Lancet Diabetes &Endocrinology
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 14 November 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Masoud Khosravipour, Mostafa Shahmohammadi, Hossein Valadi AtharAbstractBackgroundSome studies indicated night shift work can be associated with the higher risk of metabolic syndrome (MetS). However, the effects of both rotating and extended night shift work (12-hr rotating night) on MetS has not well-known. We aimed to examine and clarify the association among petrochemical workers.MethodsWe recruited 1575 eligible workers in this study. According to shift work schedules the participants we...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
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