Diabetic Nephropathy and Proximal Tubular Damage

Diabetic nephropathy (DN) is a major cause of uremia in developed societies. Inflammation is emerging as an important mechanism for its pathogenesis and progression. Herein, we review 4 recently described cellular receptors that have been shown to mediate diabetic interstitial kidney disease. Peroxisome proliferator-activated receptor-γ attenuates STAT-1 activation and has shown promise in renoprotection. Its clinical utility is limited mainly by fluid retention through upregulation of sodium–hydrogen exchanger-3 and aquaporin-1 channels in the proximal tubule.

Source: Journal of Renal Nutrition - January 8, 2015 Category: Urology & Nephrology Authors: Sydney C.W. Tang, Wai Han Yiu, Miao Lin, Kar Neng Lai Tags: ICURT PROCEEDINGS Source Type: research