Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure

TRAIL is best known for killing cancer cells selectively, however, some cancers resist TRAIL treatment for various reasons. Esophageal adenocarcinoma is such an example. Previously, we reported that the tumor cells interrupted TRAIL-mediated apoptosis by overexpressing the decoy receptors and survivin.

Source: Digestive and Liver Disease - June 3, 2020 Category: Gastroenterology Authors: Zhiheng Chang, Tong Dang, Na Che, Hui Yu, Jianyuan Chai, Weichang Chen Tags: Oncology Source Type: research