Assessment of metabolic pattern in betel quid dependence individuals brain using 18F-FDG-PET

1560Objectives: Over 600 million people regularly chewed betel quid though it is well investigated to be associated with oral, pharyngeal, and esophageal cancer. Unlike other abused substances, little research about betel quid dependence (BQD) inducing damage of the brain has studied in the past, especially with PET/CT. The primary object of this study was to identify the metabolic pattern of BQD individual’s brains using 18F-2-fluoro-2-deoxy-D-glucose-PET (18F-FDG-PET). Methods: The study was approved by the institutional review board. A total of 42 individuals (16 BQD individuals and 26 healthy controls) who underwent brain 18F-FDG-PET were enrolled. The inclusion criteria is the patient who has consumed any type of betel or betel quid product per day for at least 6 months, and had the diagnosis of DSM-IV BQ-D. Process imaging and group comparisons were carried out with statistical parametric mapping 12 (SPM12) to identify a 18F-FDG-PET pattern, basic models design at a two-sample t-test. Characteristics of abnormal metabolism brain region quantified by xjView Matlab toolbox, we selected abnormal metabolism areas with a significance of p
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research

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