[11C]UCB-J PET imaging of synaptic vesicle protein SV2A in cognitive decline

Conclusions: For all four subjects in cognitive decline, [11C]UCB-J binding is reduced in the hippocampus when compared to the cognitively unimpaired A-/T- subjects. Decreased binding in the parahippocampus, inferior parietal lobe, medial frontal lobe, and/or the entorhinal cortex was also observed in some of those cases. Ongoing, longitudinal studies with larger sample sizes will investigate associations between cognitive, amyloid, and tau status with [11C]UCB-J measured synaptic density.

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: DiFilippo, A., Tullis, T., Zammit, M., Murali, D., McKinney, G., Davenport, N., Barnhart, T., Betthauser, T., Engle, J., Stone, C., Johnson, S., Bendlin, B., Christian, B. Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research