The use of 18F-Fluciclovine PET/CT Scan in the detection of recurrent prostate cancer in non-prostatectomy patients

1247Background: While the diagnostic performance of 18F-FACBC PET/CT imaging in the restaging of patients with biochemical recurrence (BCR) after initial prostatectomy is well documented, its clinical utility in patients with BCR following primary non-prostatectomy treatments is unknown. We aimed to determine detection rate of 18F-FACBC PET/CT scan and the patterns of prostate cancer recurrence in patients with suspected BCR after initial non-prostatectomy treatments, particularly in patients with PSA levels below the accepted Phoenix definition of PSA failure (PSA nadir + 2). Methods: In this single tertiary institution study, we retrospectively enrolled consecutive patients who underwent an 18F-FACBC PET/CT scan between 2017 and 2020 for elevated PSA level following definite initial external beam radiation therapy, brachytherapy and/or cryoablation of prostate cancer. Relevant clinical information including initial treatment, demographic data, PSA level, PSA nadir, PSA kinetic parameter was collected. Receiver operating characteristic (ROC) curve was performed to determine the predictive value of PSA and PSA kinetic parameters for a positive 18F-FACBC PET/CT scan. Results: Sixty patients were enrolled in this study. The median PSA was 3.90 ng/mL. The overall detection rate for suspected recurrent prostate cancer was 85%. A total of 75% (18/24) of men below the Phoenix criteria, with median PSA of 1.7 ng/mL, had scans suggestive of recurrent disease. Local recurrence was the...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: GU - non-PSMA imaging (Poster Session) Source Type: research

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This study evaluated outcomes associated with a high-dose-rate (HDR) brachytherapy boost combined with stereotactic body radiation therapy (SBRT) for patients with higher-risk localized prostate cancer.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Curr Issues Mol Biol. 2021 Aug 28;43(2):996-1018. doi: 10.3390/cimb43020071.ABSTRACTActive constituents isolated from Euodia ruticarpa (ER) steam distilled essential oil (SDEO) against PC-3 prostate cancer cell growth remain unclear. To clarify the puzzle, ER SDEO was extracted and further resolved into six isolated fractions ERF1-F6 with Sephadex LH-20 gel filtration chromatography to analyze their biological activities. Active ingredients in the isolated fractions were analyzed with GC-MS. Potential isolated fractions were selected to treat PC-3 cells with direct action and indirect treatment by mouse splenocyte- (SCM) a...
Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Source Type: research
Curr Issues Mol Biol. 2021 Aug 28;43(2):996-1018. doi: 10.3390/cimb43020071.ABSTRACTActive constituents isolated from Euodia ruticarpa (ER) steam distilled essential oil (SDEO) against PC-3 prostate cancer cell growth remain unclear. To clarify the puzzle, ER SDEO was extracted and further resolved into six isolated fractions ERF1-F6 with Sephadex LH-20 gel filtration chromatography to analyze their biological activities. Active ingredients in the isolated fractions were analyzed with GC-MS. Potential isolated fractions were selected to treat PC-3 cells with direct action and indirect treatment by mouse splenocyte- (SCM) a...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Source Type: research
Chem Biodivers. 2021 Sep 24. doi: 10.1002/cbdv.202100301. Online ahead of print.ABSTRACTIsorhamnetin is a natural flavonoid which shows a variety of biological activities such as antioxidant, anti-inflammation and antitumor. In order to identify the cellular binding protein of isorhamnetin as potential anti-cancer target, we first synthesized 3'- O -substituted quercetin as isorhamnetin analogues and evaluated the growth inhibitory activity of these derivatives on breast, colon and prostate cancer cell lines. The preliminary results showed that the 3'- O modification did not affect the cytotoxic activity of the scaffold. A...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research
Environ Res. 2021 Sep 22:112085. doi: 10.1016/j.envres.2021.112085. Online ahead of print.ABSTRACTBecause of their historical mode of action, endocrine-disrupting chemicals (EDCs) are associated with sex-steroid receptors, namely the two estrogen receptors (ERα and ERβ) and the androgen receptor (AR). Broadly, EDCs can modulate sex-steroid receptor functions. They can also indirectly impact the androgen and estrogen pathways by influencing steroidogenesis, expression of AR or ERs, and their respective activity as transcription factors. Additionally, many of these chemicals have multiple cellular targets other th...
Source: Environmental Research - Category: Environmental Health Authors: Source Type: research
Objective:To provide commentary on the disparities in access to clinical trials and precision oncology specific to Black men with Prostate Cancer (PCa) in the United States and lend a general framework to aid in closing these gaps.Materials and Methods: The ideas, commentaries and data presented in this narrative review were synthesized by utilizing qualitative and quantitative studies, reviews, and randomized control trials performed between 2010 and 2021. We searched PubMed using the key words “Medicaid”, “Medicare”, “clinical trials”, “African Americans”, “Black&rdqu...
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Conditions:   Prostate Adenocarcinoma;   Prostate Carcinoma Intervention:   Procedure: Magnetic Resonance Imaging Sponsor:   M.D. Anderson Cancer Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article reviews the abnormal expression of miR-802 in a variety of tumors, expounds the mechanism by which miR-802 affects tumor progression by regulating different target genes, and elaborates the network of miR-802-related ceRNAs. We also summarized the limitations of miR-802 research and looked forward to the potential application of miR-802 in the diagnosis and prognosis of tumors.PMID:34558723 | DOI:10.1002/jcla.23989
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
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Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Am J Clin Oncol. 2021 Sep 27. doi: 10.1097/COC.0000000000000866. Online ahead of print.ABSTRACTOBJECTIVES: Metastatic cancer has historically been considered fatal; however, there is a paucity of evidence characterizing the epidemiology of incidence, treatment, and outcomes in these patients.MATERIALS AND METHODS: Incidence rates, annual percent change (APC), descriptive epidemiological statistics, and odds ratios for survival were calculated using registry data from the Surveillance, Epidemiology, and End Results (SEER) and the National Cancer Database (NCDB), 1998 to 2015.RESULTS: There were a total of 1,055,860 patients...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
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