[89Zr]-PSMA Df offers a prolonged time frame for prostate cancer imaging: A comparison with short-lived PSMA tracers.

Conclusions: This study demonstrates that the tumor uptake and biodistribution of [89Zr]-PSMA Df in normal tissues is comparable to that of [68Ga]-PSMA 11 and [18F]-JK-PSMA 7, but remains in the tumor for at least 52 h p.i. with increasing tumor-to-background ratio. This, together with the long half-life of the [89Zr]-label allows late PET-acquisition with improved lesion detection. Tumors with lower PSMA expression are thus more likely to be detected than with existing 18F- or 68Ga labeled PSMA targeted imaging agents.

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Munoz Vazquez, S., Endepols, H., Fischer, T., Hohberg, M., Zimmermanns, B., Dietlein, M., Neumeier, B., Drzezga, A., Schomaecker, K. Tags: Basic Oncology & amp; Translational (Poster Session) Source Type: research