Synthesis of a carbon-11 labeled ligand targeting trace amine associated receptor 1
Conclusion: We have successfully radiolabeled a potent TAAR1-selective antagonist in high radiochemical yield and high molar activity. Further ADME optimization will be performed in order to improve brain permeability and guide the development of the next-generation TAAR1 PET ligands. References: [1] Cell Mol Neurobiol. 2019, Doi:10.1007/s10571-019-00772-7; [2] Bioorg. Med. Chem. Lett. 2011, 21(4), 1227-1231.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: SUN, J., Chen, J., Chen, Z., Shao, Y., WANG, L., Xu, H., Liang, S. Tags: Radiochemistry and Chelation (Poster Session) Source Type: research
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