In vitro and in vivo PET imaging properties of [18F]KS1, a fluroethoxy ascorbate derivative to track reactive oxygen species in cancer

Conclusions: KS1 do not generate ROS in tumor cells at tracer level concentrations (≤100 uM) and tumor-killing properties by inducing ROS generation at pharmacologic doses (≥1.0 mM), and behave like ascorbate. [18F]KS1 exhibited high tumor uptake in vivo, with superior specificity and selectivity, and favorable pharmacokinetics in several tumor-bearing mice. This would be the first [18F]-based PET tracer, based on a natural vitamin to image ROS in tumor cells in vivo, with a clear mechanistic profile. Based on our promising data, we hypothesize that ascorbate-based PET ligand strategy will expand the ascorbate scaffold for potential imaging agent(s) to image ROS in vivo. 1Solingapuram et al; EJNMMI 2019, 9 (1), 43.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology (Poster Session) Source Type: research