Development of [11C]mG3N001 as a PET imaging ligand for metabotropic glutamate receptor 3 (mGluR3)

Conclusions: Our preliminary PET imaging studies demonstrated that [11C]mG3N001 has good brain penetration which may serve as a promising PET probe for neuroimaging of mGluR3. As far as we know, this is the first mGluR3-selective PET imaging probe. Acknowledgements: The studies were supported by NIH/NIA K25AG061282 and NIH/NINDS R01NS100164 for generously providing funding for this research.

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Wang, J., Wang, C., El Fakhri, G., Caravan, P., Zhang, Z., Brownell, A.-L. Tags: Preclinical Probes for Neuroimaging (Poster Session) Source Type: research