Towards the clinical translation of the adenosine A2A receptor (A2AR) radiotracer [18F]FLUDA: pre-clinical perspectives

Conclusions: The fully automated radiosynthesis of [18F]FLUDA allows its translation to clinical radiopharmacy. [18F]FLUDA exhibited an A2AR-specific accumulation in the striatum in vitro and in vivo. No safety concerns are expected upon administration of [18F]FLUDA according to toxicity and dosimetry studies. Altogether, these results encourage the performance of clinical trials to validate the potential of [18F]FLUDA for PET imaging of neuronal, cardiovascular and cancer-related diseases. Acknowledgment: The authors thank the European Regional Development Fund and Sächsische Aufbaubank (SAB) for financial support (project no. 100226753). [1] Sattler, B. et al. (2020) this volume.

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Teodoro, R., Lai, T. H., Toussaint, M., Gundel, D., Dukic-Stefanovic, S., Deuther-Conrad, W., Schroder, S., Kranz, M., Moldovan, R.-P., Brust, P. Tags: Preclinical Probes for Neuroimaging II Source Type: research