Evaluation of 18F-FGA PET/CT for specific imaging of necrotic tissue in a mouse model of coronary artery ligation

Conclusions: Results indicate that FGA accumulates in necrotic tissue of MI heart, which could be employed for discriminatory imaging of salvageable ischemic tissue from non-viable tissue. This highly specific and positive predictive value information has potential to impact clinical decisions in management of MI patients. Mechanistically, FGA appears to target hitherto unknown nuclear proteins exposed after necrotic cell death.

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Gali, H., Mdzinarishvili, A., Hedrick, A., Da, H., Awasthi, V. Tags: New Techniques and Tracers for Ischemic Heart Disease (Basic Science, Cardio) Source Type: research