Spatial distribution of neurofibrillary tau with A{beta} load distinguish cases of cognitive impairment and Alzheimers disease from cognitively stable individuals with Down syndrome

218Background: Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD), with most developing clinical dementia by their late 60s. While Aβ pathology has been previously characterized in this population, its relationship with neurofibrillary tau is much less well understood. Objectives: The focus of this study is to determine the associations between global Aβ and regional tau in DS, as well as assess the differences in these biomarkers between cognitively stable adults with DS (CS) and cases of cognitive impairment (MCI/AD). Methods: A total of 140 adults with DS (age = 39.3 ± 8.4 years) were evaluated for Aβ and tau using [C-11]PiB and [F-18]AV-1451 PET as part of the ongoing Alzheimer’s Biomarker Consortium-Down Syndrome study (ABC-DS). A consensus on the cognitive status was determined through neuropsychological examination and caregiver report - independent of the PET scans. The MCI/AD group consisted of 13 participants while the CS group contained 117. Cognitive status was unable to be determined for the remaining 10 (excluded from the group analysis). 50-70 minute PiB SUVr and 80-100 minute AV-1451 SUVr images were created using cerebellar gray matter as a reference region. The Amyloid Load index (AβL) was calculated from the PiB SUVr images to determine global Aβ burden. Participants were classified as Aβ(+) if their AβL exceeded 20% (Zammit, 2020). Regional AV-1451 SUVr values were extracted base...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science - Inflammation and Dementia Source Type: research

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ConclusionDisorders associated with early-life alterations in amyloid precursor protein production or processing are associated with a distinct pattern of early striatal fibrillary Aβ deposition before significant cognitive impairment. A better understanding of this unique pattern could identify important mechanisms of Aβ deposition and possibly important targets for early intervention.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
PHILADELPHIA - A study on amyloid plaque accumulation, white-matter hyperintensity,...Read more on AuntMinnie.comRelated Reading: Are amyloid PET scans ready for the clinical setting? PET links amyloid, vascular factors to cognitive decline PiB-PET study strengthens link between amyloid, dementia High amyloid levels on PET may indicate early Alzheimer's SNMMI: PiB-PET finds unique Down syndrome trait
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
The presence of amyloid on PET scans may be a sign that adults with no symptoms...Read more on AuntMinnie.comRelated Reading: High amyloid levels on PET may indicate early Alzheimer's PiB-PET could open window on common meningiomas SNMMI: PET shows tau may be Alzheimer's catalyst SNMMI: PiB-PET finds unique Down syndrome trait PiB-PET shows link between arterial stiffness and beta amyloid
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: 2018 Source:NeuroImage: Clinical, Volume 17 Author(s): Natalie Neale, Concepcion Padilla, Luciana Mascarenhas Fonseca, Tony Holland, Shahid Zaman People with Down syndrome (DS) develop Alzheimer's disease (AD) at higher rates and a younger age of onset compared to the general population. As the average lifespan of people with DS is increasing, AD is becoming an important health concern in this group. Neuroimaging is becoming an increasingly useful tool in understanding the pathogenesis of dementia development in relation to clinical symptoms. Furthermore, neuroimaging has the potential to play a role in ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Scientists at the University of Edinburgh’s Centre for Cognitive and Neural Systems have found evidence that long-term testing starting well before any signs of Alzheimer’s symptoms are evident could be a valuable tool in detecting which people will need intervention with therapeutic drugs that are now in clinical trials. This type of intervention could possibly halt or even reverse cognitive damage while the patient is still symptom-free. The long-term testing would be done in conjunction with brain scans. Read full article on HealthCentral about the value of long-term testing: Support a caregiver or jump star...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
DISCUSSION: PIB binding in DS, first appearing in striatum, began around age 40 and was strongly associated with dementia and cognitive decline. The absence of a substantial time lag between amyloid accumulation and cognitive decline contrasts to sporadic/familial AD and suggests this population's suitability for an amyloid primary prevention trial. PMID: 26362596 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Discussion PIB binding in DS, first appearing in striatum, began around age 40 and was strongly associated with dementia and cognitive decline. The absence of a substantial time lag between amyloid accumulation and cognitive decline contrasts to sporadic/familial AD and suggests this population's suitability for an amyloid primary prevention trial.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
People with Down syndrome are at much higher risk of developing dementia, researchers say Source: HealthDay Related MedlinePlus Pages: Alzheimer's Disease, Diagnostic Imaging, Down Syndrome
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news
This study provides a foundation for the studies needed to inform treatment and prevention in DS. PMID: 25849033 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
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