Study of ALS and RAGE Using [11C]PBR28: Mechanisms and Therapeutic Opportunities

Conclusions: Inconsistent outcomes have been reported in the literature when comparing TSPO ligand binding for imaging neuroinflammation. Our data are consistent with findings from several recent studies; i.e., reduced PBR28 binding was associated with disease state (e.g., in patients with PTSD or alcoholism). A notion that the reduced binding might reflect competition from endogenous TSPO ligands such as cholesterol can’t be excluded. The strategies described here will test the hypothesis that pharmacological antagonism of RAGE signal transduction in either initiation or progression phases of the ALS will prolong survival and maintain motor function in adult Sod1G93A mice.

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Wang, J., MacLean, M., Youss, Z., Mishkit, O., Clancy, D., Jackson, R., Juranek, J., Carlucci, G., Schmidt, A. M., Ding, Y.-S. Tags: Basic Science - Inflammation and Dementia Source Type: research