TREM1-PET imaging of pro-inflammatory myeloid cells distinguishes active disease from remission in Multiple Sclerosis

CONCLUSION: TREM1-PET successfully discriminated active disease and remission in RR-EAE mice. Furthermore, this is the first report of the presence of TREM1+ cells in human MS brain. Thus, TREM1-PET has high potential for clinical impact on disease and therapeutic monitoring for individual RR-MS patients.

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Chaney, A., Wilson, E., Jain, P., Cropper, H., Swarovski, M., Lucot, K., Vogel, H., Andreasson, K., James, M. L. Tags: Preclinical Probes for Neuroimaging I Source Type: research